Ea Pharma Co., Ltd.

Ajinomoto Co., Ltd.

Kaori Kobayashi

Tamotsu Suzuki

Koji Ohsumi

Tatsuya Okuzumi

Masayuki Sugiki

Tadakiyo Nakagawa

Munetaka Tokumasu

Sayaka Asari

Sen Takeshita

Kayo Matsumoto

Tomomi Yoshida

Tomohiro Fujii

Seiji Shiraishi

Hiroki Inoue

Mizuki Kawahira

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.

Heterocyclic sulfonamide derivative and medicine comprising same

Compounds of represented by formula (I): wherein each symbol is defined herein and pharmaceutically acceptable salts thereof exhibit TRPA1 antagonist activity and are useful as TRPA1 antagonists and the prophylaxis or treatment of diseases involving TRPA1.

Heterocyclic sulfonamide derivative and medicine containing same

The present invention aims to provide a novel compound having a TRPA1 antagonist activity, and a medicament containing the compound. Moreover, the present invention aims to provide a TRPA1 antagonist and a medicament useful for the prophylaxis or treatment of diseases involving TRPA1. A medicament containing a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof, and the like.

Heterocyclic amide derivative and pharmaceutical product containing same

Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe.  In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Aris represented by any one of the following rings and the like. 

Pharmaceutical composition for treating diabetes

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Kawasaki, Japan

Kaori Kobayashi