Tohoku University

Kaori Itto

Daiki Takahashi

Hirokazu Arimoto

Nobuo Cho

Naoki Ishii

Taiichi Ohra

Kenichiro Shimokawa

Hiroshi Nara

Jun Moriyama

Shigekazu Sasaki

Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.

Heterocyclic compound

Provided is a degrader for injured mitochondria based on an autophagy mechanism, the degrader including a compound or a salt thereof, the compound containing a ligand capable of binding to or accumulating in mitochondria and a substituent represented by the following general formula (1): where R, R, and Rare identical to or different from each other, and each represent a hydrogen atom or the like.

Degradation agent using autophagic mechanism of damaged mitochondria

Growing community of inventors

Miyagi, Japan

Kaori Itto