Daiichi Sankyo Company, Limited

Yokoyama, Shigeyuki

Kaori Ito

Yasuyuki Ogawa

Keiji Saito

Katsuyoshi Nakajima

Toru Taniguchi

Osamu Iwamoto

Nobuya Kurikawa

Eriko Kioi

Shinji Tanaka

Kazumasa Aoki

Satoshi Shibuya

Momoko Ogitani

Natsumi Nishihama

Wataru Saitoh

Tsuyoshi Mikkaichi

Seiko Nagata

Makoto Hirasawa

Mitsuhiro Makino

Yoshihiro Nakamura

Shigeyuki Yokoyama

Yoshiko Katsura

Naoko Nomura

Takehiro Shinoda

Tetsuya Hori

Hiroaki Tanabe

Mikako Shirouzu

Tomomi Someya

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., —CH—, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R, R, R: e.g., a halogen atom, R: e.g., a C1-C6 alkyl group, R: e.g., a hydrogen atom, R, R, R, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, n, n, n: e.g., 1.

Compound having cyclic structure

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R: e.g., a C1-C6 alkyl group; R: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R: e.g., a C1-C6 alkyl group.

Griseofulvin compound

The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R: a C1-C6 alkyl group or the like, R: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R, R': a C1-C6 alkyl group or the like].

Griseofulvin compound and pharmaceutical use thereof

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below:R: e.g., a C1-C6 alkyl group; R: a C1-C6 alkyl group;A: e.g., an oxygen atom; and R: e.g., a C1-C6 alkyl group.

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below:A: e.g., Benzene, E: e.g., &#x2014;CH&#x2014;, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R, R, R: e.g., a halogen atom, R: e.g., a C1-C6 alkyl group, R: e.g., a hydrogen atom, R, R, R, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, n, n, n: e.g., 1.

The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R: a C1-C6 alkyl group or the like, R: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R, R: a C1-C6 alkyl group or the like.

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Koto-ku, Japan

Kaori Ito