Dainippon Sumitomo Pharma Co., Ltd.

Kantaro Ushiroda

Ryu Nagata

Katsunori Maruta

Yoko Takahashi

Kozo Yoshida

Makoto Kitoh

Kiyotaka Iwai

Ken-ichi Watanabe

A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc.  wherein the ring Z is an optionally substituted heteroaryl, Wis a single bond, lower alkylene, etc., Aris an optionally substituted aryl, etc., Wis a single bond, lower alkylene, etc., Aris an optionally substituted arylene, etc., each of Wand Wis an optionally substituted lower alkylene, etc., and Ris carboxyl, an alkoxycarbonyl.

Heteroaryl derivatives

A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, Ris a carboxyl group or an alkoxycarbonyl group, etc., Wand Ware an optionally substituted lower alkylene, Aris an optionally substituted arylene or an optionally substituted heteroarylene, Wis a single bond, a lower alkylene, a lower alkenylene, etc., Wis a single bond, &#x2014;NR&#x2014;, etc., Aris an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

Heteroaryl derivative

A novel pyrrole derivative represented by the following formula (1) and a salt thereof: wherein Rmeans substituted alkenyl, etc.; Rmeans substituted benzoyl, etc.; and Rto Reach means hydrogen, alkyl, halogeno, etc. The derivative and salt have antidiabetic activity.

Pyrrole derivative

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Osaka, Japan

Kantaro Ushiroda