Medimmune Limited

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Cel-sci Corporation

National Institute of Health

Medimmune Vaccines, Inc.

The Government of the United States of America National Institutes of Health

Kanta Subbarao

Brian R Murphy

George William Kemble

Chin-Fen Yang

Hong Jin

Xing Cheng

Daniel H Zimmerman

Eyal Talor

Kobporn Boonnak

Brian Murphy

The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of influenza virus and other infectious diseases. Compositions containing the same, methods for producing the same, and methods for using the same are also disclosed, wherein the peptide constructs have the formula P-x-P, where Pis a peptide associated with an infectious agent and Pis a peptide that will bind to a class of immune cells, such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cell can be administered to a subject to modulate or initiate an immune response against an infectious agent. Dyes, radioisotopes, or therapeutic agents conjugated with the dendritic cells can be used for localization of the immune target and/or prophylactic or therapeutic treatment of the disease.

Method for inducing an immune response and formulations thereof

Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided.

Influenza hemagglutinin and neuraminidase variants

Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.

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Washington, DC, United States of America

Kanta Subbarao