The Kitasato Institute

Other

Kanki Komiyama

Iwao Umezawa

Hideo Takeshima

Satoshi Omura

Masahiko Hayashi

Shigeo Hasegawa

Juichi Awaya

Ruiko Oiwa

Kazuhiko Otoguro

Yutaka Miyauchi

Shinji Funayama

Keiki Satoh

Satoshi Takamatsu

Citrus amanatsudaidai peel extract, which was used as a starting materials was purified over various kinds of column chromatography (activated carbon, Amberlite IR-120B [H.sup.+ ], cellulose, Sephadex G25 and HPLC) to isolate a peptide as a white powder. This peptide is a water-soluble neutral substance and shows positive reactions to ninhydrin and sodium nitroprusside and negative reactions to anisaldehyde, phenolsulfuric acid and Dragendorff reagent. Amino acids constituting the peptide of the present invention contain aspartic acid and oxylysine in large amounts. Hair growers containing the peptide of the present invention were successful in promoting 150% proliferation of rabbit hair papilla cells when applied in a concentration of 1.4 .mu.g/ml.

Peptides and hair growers having actions of promoting proliferation of

Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive substances K93-0711 I-1 and I-2 accumulate in the medium. These bioactive substances K93-0711 I-1 and I-2 are then isolated therefrom. The substances are effective for treatment of IL-6-involving diseases such as cancer cachexia, multiple myeloma and rheumatoid arthritis.

Bioactive substances K93-0711 I-1 and I-2 and process for production

Antibiotic 82-85-8A, or a pharmacologically acceptable non-toxic salt thereof, having the following physicochemical properties:

Novel cell-cidal antibiotic 82-85-8A and its production

A novel antibiotic, awamycin, and its production. Awamycin is active against gram positive bacteria and exhibits growth inhibitory activity against Erhlich ascites and Sarcoma 180 cells. Some of the identifying characteristics of awamycin include a molecular weight of 744.+-.1 (mass spectrum analysis), an elementary analysis of 59.16% C, 6.48% H and 1.88% N; a melting point of 158.degree. C.; an optical rotation of [.alpha.].sub.D 24=+836.degree.. Awamycin is an acidic substance, which provides an orange colored powder, and is poorly soluble in water.

Novel antitumor antibiotic awamycin and its production

Antibiotic 81-484 of the following physico-chemical properties:

Antitumor antibiotic 81-484 and process for its production

A new acidic polysaccharide is isolated from a culture of cells of the algae Chlorella pyrenoidosa. The process for producing this polysaccharide is also disclosed. This substance exhibits antitumor activity and antiviral activity and induces the production of interferon.

Acidic polysaccharide CH-1 isolated from Chlorella pyrenoidosa and the

A novel proteinous substance KUP-PC, which is produced by culturing proteinous substance KUD-PC producing organisms belonging to the genus Streptosporangium. KUD-PC increases the antitumor activity of the anti-tumor substance, sporamycin.

Novel proteinous substance KUD-PC and its production

This invention relates to the antibiotic stubomycin and process for producing same by culturing streptomyces sp KG - 2245 FERM-P No. 5675

Antibiotic stubomycin and process for the production thereof

A novel antibiotic sporamycin has both anti-transplanted tumor and antibacterial activity and is produced by culturing a microorganism of the genus Streptosporangium, particularly Streptosporangium pseudovulgare PO-357 FERM-P No. 3571, ATCC No. 31308.

Antibiotic sporamycin

The present invention relates to a new antibiotic designated as OS-3256-B. OS-3256-B exhibits excellent inhibitory activities against animal tumors such as leukemia L-1210, Sarcoma-180 and Hela cells and gram-positive bacteria and is classified into the diazocompounds group. However, chromatographic analysis, Rf value and other experimental data reveal that OS-3256-B is a new compound of the type of azaamino acid derivatives. The present invention also provides a process for producing OS-3256-B by fermentation, in which OS-3256-B is produced by culturing a microorganism belonging to Streptomyces candidus var. azaticus in a culture medium conventionally used for culturing Streptomyces strain microorganisms.

Growing community of inventors

Yokohama, Japan

Kanki Komiyama