Hisamitsu Pharmaceutical Company, Inc.

Teijin Limited

Toyo Ink Manufacturing Company

Kanji Noda

Akira Nakagawa

Hiroyuki Ide

Masaru Saita

Terumi Hachiya

Masayoshi Tsuji

Hisataka Inoue

Toshiharu Motomura

Akihide Koda

Munehiko Hirano

Yasuaki Taniguchi

Satoru Miyata

Yoshiki Deguchi

Yoichi Nakashima

Kenji Yamagata

Tetsuya Yamagata

Shigenori Yahiro

Yuji Ishikura

Yasunori Takada

Mikio Nakashima

Yasuhiro Ikeura

Yasuhisa Kose

Keisuke Kaiho

Yusaku Ide

Itsuo Nishioka

Risaburo Yoshida

Shoji Hamanaka

Hirotsune Igimi

Ikuo Shinohara

Yoshihiro Tanoue

Terushi Hashiguchi

Toyoaki Yoneda

Kazuki Furuya

Ryuhei Kodama

Hideaki Inoue

Kazuhide Furukawa

Tadanori Yano

Hirotaka Kida

Taniguchi: Yasuaki

Hidetoshi Amano

Yasushi Haraguchi

Koichiro Ueda

Tadayoshi Suenaga

Akira Yagi

Noriyuki Fujimoto

Kouichi Beppu

Masasi Kobayasi

Kouichi Ikesue

Fumiaki Tokubuchi

Kazuki Noguchi

Hidenao Minami

Tadaaki Yoshitake

Tetsuo Aoki

Kenichi Furuta

Eiji Kyoya

Ketorolac-containing fomentation

Diphenylthiazole derivative

Process for producing azacycloalkane derivatives

Dibenz[b,e]oxepin derivatives

A novel 3-aroyl-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-7-carboxylic acid derivative which is useful as a medicine having excellent analgesic and anti-inflammatory actions with remarkably less toxicity and side-effects.

3-aroyl-6,7-dihydro-5H-pyrrolo(1,2-c)imidazole-7-carboxylic acid

A novel plaster comprising a thermoplastic elastomer, an oil or higher fatty acid, a tack-providing resin and a medicinal ingredient. The plaster may be easily released therefrom without giving appreciable irritation or pain to the skin and body hairs of human bodies after applied thereto, while it may nevertheless exhibit satisfactory tackiness and adhesive strength when applied to human bodies.

Novel plasters

Novel 2,3-dihydro-indene derivatives having remarkable anti-inflammatory effects and represented by the following formula ##STR1## wherein R.sup.1 and R.sup.2 are each a hydrogen atom, halogen atom, nitro group, lower alkyl group or lower alkyloxy group with the proviso that R.sup.1 and R.sup.2 do not take a hydrogen atom at the same time, and n is an integer of 2-4.

2,3-Dihydro-indene derivatives

An antiallergic composition comprising, as the effective ingredient, a compound represented by the following general formula ##STR1## wherein R is n-butyl group or n-pentyl group, the compound being preferably supported by a carrier such as sugar, starch, gum arabic or calcium stearate.

Antiallergic compositions

A process for the preparation of an isoindoline derivative of the following general formula (II): ##STR1## wherein R.sup.2 is a hydrogen atom or lower alkyl group and X is a carboxyl group, carboalkoxy group, amide group or cyano group, which comprises

Novel process for preparing isoindoline derivatives

An alkyl-ketohexopyranoside derivative having pharmacological actions such as antiallergic actions, represented by the following general formula ##STR1## wherein R is an alkyl group having at least 3 carbon atoms, the derivatives excluding the D-fructose derivative wherein R is n-propyl group.

Alkyl-ketohexopyranoside derivatives and method of use

An anti-inflammatory analgesic gel composition comprising (1) ketoprofen and/or flurbiprofen as the effective ingredient, as well as (2) a glycol, lower alcohol, water and/or a mixture of a lower alcohol with water, (3) a gel-forming agent and, if desired, (4) a solubilizing agent and/or non-ionic surface-active agent as the ingredients of a gel base for the gel composition.

Anti-inflammatory and analgesic gel composition

Novel anthranilic acid derivatives of the general formula: ##STR1## wherein X is a halogen atom, an alkoxyl group having 1-3 carbon atoms, an alkyl group having 1-3 carbon atoms or a nitro group, n is an integer of 1-2, Y is an alkoxyl group having 1-3 carbon atoms, m is an integer of 2-3, Z is --COCH.dbd.CH-- or --CO--, R.sub.1 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, and pharmaceutically acceptable salts thereof, which derivatives and salts possess a strong antiallergic action and are thus useful as therapeutically active agents for diseases caused by allergies, such as asthma, hay fever, urticaria and atopic dermatitis; an antiallergic composition comprising the same; and a method of alleviating diseases caused by allergies using the same.

Novel anthranilic acid derivatives

The present invention relates to the phenyl-propionic acid ester derivative of the following formula: ##STR1## The compound obtained by the present invention possesses a high degree of analgetic, antipyretic and anti-inflammatory activity and causes little side effects on the gastro-intestinal tracts, when administered orally and topically, and it may be useful as an oral and topical analgesic, antipyretic and anti-inflammatory agent.

Phenyl-i-propionic acid esters and pharmaceutical use thereof

The present invention relates to novel cyclohexanecarboxylic acid and its derivatives represented by the general formula: ##STR1## (wherein R.sup.1 is selected from the group consisting of hydrogen or methyl; R.sup.2 is selected from the group consisting of hydroxyl, lower alkoxy with 1-6 carbons or amino acid rest. In case R.sup.1 is hydrogen, however, R.sup.2 means amino acid rest, which of all the compounds of the present invention are entirely novel ones which have never been in any printed publications, possessing a high degree of pharmacological activities such as anti-allergic, anti-inflammatory, anti-ulcerative, antibacterial, anti-thrombotic and liver-function-improving activities, and therefore, these compounds are useful as medicines, and besides, these compounds are surface-active and, therefore, useful as additives for toothpaste and shampoo, as surface active agents for detergents, dispersing agents, emulsifying agents and cosmetics, as anticarious agents, and also in industrial fields the aforesaid compounds are useful as detergents for keeping textiles soft, as additives for lubricating oil, as anti-rust agents, additives for plastics and also as metal-capturing agent, ion-floating agents and emulsifying agents for other industrial purposes).

Novel cyclohexanecarboxylic acid and its derivatives

A thermogenic sheet combined poultice comprising a thermogenic composition layer capable of generating heat in the presence of air or oxygen and a heat-stable wet pack composition layer; and a process for the production of the thermogenic sheet combined poultice.

Thermogenic sheet-combined poultices

Growing community of inventors

Chikushino, Japan

Kanji Noda