L.e.a.f. Holdings Group LLC

Kaniz Khalifa

Victor Mandla Moyo

Clet Niyikiza

Zhenghong Xu

Bolin Geng

Gwangseong Kim

Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

Carotenoid compositions and uses thereof

This disclosure relates to a targeted PEGylated liposomal gemcitabine (PLG) composition comprising a PEGylated liposome encapsulating one or more agents comprising gemcitabine and a targeting moiety; pharmaceutical composition and methods comprising PLG or producing PLG; and manufacturing equipment for performing the methods.

Targeted liposomal gemcitabine and methods thereof

Targeted liposomal gemcitabine compositions and methods thereof

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Billerica, MA, United States of America

Kaniz Khalifa