University of California

Kanianthara G Chandy

George A Gutman

Brent A Dethlefs

Michael D Cahalan

Stephan Grissmer

Katalin Kalman

Alan L Goldin

John J Wasmuth

Sanjiu Ghanshani

Grischa Chandy

This disclosure relates to the n K.sup.+ channel expression product of the MK3 gene or a functionally bioactive equivalent thereof and its uses, particulary in combination with identifying immune responses and materials modulating or blocking same.

Assay, methods and products based on n K.sup.+  channel expression

This disclosure relates to the identification of a new voltage-gated potassium channel gene, Kv1.7, which is expressed in pancreatic .beta.-cells. The invention utilizes this new potassium channel for assays designed to identify extrinsic materials with the ability to modulate said channel for the development of therapeutics effective in the treatment of non-insulin-dependent diabetes mellitus.

Voltage-gated potassium channel gene, KV1.7, vectors and host cells

This disclosure relates to the general diagnosis and treatment of autoimmune diseases with materials identified in assays based upon the finding herein that such diseases manifest by elevated numbers of type l K.sup.+ channels in abnormal CD4.sup.- CD8.sup.- T cells.

Assay for and treatment of autoimmune diseases

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Laguna Beach, CA, United States of America

Kanianthara G Chandy