Jiangsu Alphamab Biopharmaceuticals Co., Ltd.

Suzhou Alphamab Co., Ltd.

R-pharm International LLC

Kangping Guo

Ting Xu

Xiaoxiao Wang

Yuhao Jin

Pilin Wang

Dong Yang

Qian Li

Yan Lavrovsky

Vasily Ignatiev

Alexey Repik

Mikhail Samsonov

Lihong Yun

Disclosed are a method for treating a tumor using a CTLA4-binding protein and a use thereof, wherein the CTLA4-binding protein specifically binds to CTLA4 and does not compete with a ligand of CTLA4 for binding to CTLA4. The CTLA4-binding protein described in the present application can effectively inhibit tumor growth.

Method for treating tumor using anti-CTLA4 single-domain antibodies

The present disclosure provides a dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4.

Dimers and use thereof

Disclosed herein is a gonadotropin fusion protein or a thyroid stimulating hormone fusion protein, a method for preparing the same and use thereof. &#x3b2;-subunit of the gonadotropin or thyroid stimulating hormone is fused to an Fc fragment directly or indirectly through a linker, and &#x3b1;-subunit binds to the &#x3b2;-subunit via an affinity between the &#x3b1;-subunit and the &#x3b2;-subunit. The fusion protein has a prolonged half-life and less fluctuating activity.

Trophic hormone fusion protein, preparation method and application thereof

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Jiangsu, China

Kangping Guo