University of California

Youhealth Biotech, Limited

Facebook, Inc.

Youhealth Oncotech, Limited

Helio Health Inc.

Other

Sage Bionetworks

Guangzhou Kangrui Biological Pharmaceutical Technology Co, Ltd.

Kang Zhang

Rui Hou

Lianghong Zheng

Qixing Du

Stephen H Friend

Jonathan M Kaldor

Joshua Li

I Chien Peng

Trey Ideker

Ashwin Bhat

Justin Guinney

Gregory Hannum

Sheng Ding

Lars Seren Backstrom

Daniel E Weaver

Adah Almutairi

Gen Li

Jiagang Zhao

Huimin Cai

Disclosed herein are methods and kits for identifying a subject as having liver cancer. Also provided herein are methods and kits for determining the prognosis of a subject having liver cancer and for determining the progression of liver cancer in a subject.

Liver cancer methylation markers and uses thereof

Disclosed herein are methods and kits for identifying a subject as having lung cancer. Also provided herein are methods and kits for determining the prognosis of a subject having lung cancer and for determining the progression of lung cancer in a subject.

Lung cancer methylation markers and uses thereof

Disclosed herein are methods and kits for identifying a subject as having colon cancer. Also provided herein are methods and kits for determining the prognosis of a subject having colon cancer and for determining the progression of colon cancer in a subject.

Colon cancer methylation markers and uses thereof

Disclosed herein are methods and compositions relating to synthesized nanopores. The synthesized nanopores can be used for detecting a target molecule (e.g. RNA, DNA, or peptide).

Methods and compositions for nanopore sequencing

Disclosed herein are methods and kits for identifying a subject as having breast cancer. Also provided herein are methods and kits for determining the prognosis of a subject having breast cancer and for determining the progression of breast cancer in a subject.

Breast and ovarian cancer methylation markers and uses thereof

Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof). Also described herein are methods of modulating the methylation pattern of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof).

Methods for evaluating, monitoring, and modulating aging process

Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.

Leukemia methylation markers and uses thereof

Disclosed herein are systems, methods, devices, and media for carrying out medical diagnosis of ophthalmic diseases and conditions. Deep learning algorithms enable the automated analysis of ophthalmic images to generate predictions of comparable accuracy to clinical experts.

Deep learning-based diagnosis and referral of ophthalmic diseases and disorders

The invention provides for methods for predicting age of a subject based on the epigenome of the subject.

Methods for predicting age and identifying agents that induce or inhibit premature aging

In one embodiment, a computing device detects an event corresponding to a change in a graphical user interface displayed by the computing device; the computing device identifies at least one operation based on the detected event; the computing device determines a state of the identified operation; the computing device also defers the identified operation based at least in part on the determined state.

Defer heavy operations while scrolling

A social networking system presents a viewing user with a newsfeed of stories describing actions performed by other social networking system users. In particular, the social networking system provides a pre-fetched set of newsfeed stories to a user device of the viewing user and a presentation order for the stories. The social networking system does not 'lock' the set of newsfeed stories or the presentation order. The user device locally stores the pre-fetched ranked set of newsfeed stories upon receipt. When the viewing user later requests presentation of newsfeed stories, the user device retrieves the set of newsfeed stories and presents, to the viewing user, stories from the set according to the presentation order. A request is also sent to the social networking system to 'lock' the presented newsfeed stories and the order in which the newsfeed stories were presented.

Pre-fetching newsfeed stories from a social networking system for presentation to a user

Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the methylation profile of a biomarker associated with esophagus cancer, pancreatic cancer, or stomach cancer.

Solid tumor methylation markers and uses thereof

Disclosed herein, in certain embodiments, are methods and kits for diagnosing a subject as having hepatocellular carcinoma (HCC) or lung cancer. In some instances, also described herein are methods of determining the prognosis of the subject having HCC or lung cancer. In additional instances, described herein are methods of determining the specific staging of HCC or lung cancer in a subject.

Methylation markers for diagnosing hepatocellular carcinoma and lung cancer

The present invention provides sterols and uses thereof to treat vision disorders. In one embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat and/or prevent vision disorders in a subject. In another embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat cataract or blindness/impaired vision in a subject. In yet another embodiment, composition comprising lanosterol is used to dissolve amyloid-like fibrils of crystallin proteins.

Compositions and methods to treat vision disorders

The invention provides an in vitro method for producing isolated mammalian primitive retinal stem cells (pRSCs) comprising: (a) culturing isolated embryonic stem cells (ESCs) from a mammal in a cell culture medium that is free of feeder cells, feeder-conditioned medium or serum so as to produce and grow a culture of the isolated ESCs; and (b) contacting the culture of the isolated ESCs so grown with one or more of an inhibitor for Wnt or TGF-&#x3b2;/BMP signaling so as to differentiate the isolated ESCs of (a) into primitive retinal stem cells thereby producing isolated mammalian pRSCs.

Growing community of inventors

San Diego, CA, United States of America

Kang Zhang