Industrial Technology Research Institute

Kang-Li Wang

Pei-Shin Jiang

Ping-Fu Cheng

Tseng-Huang Liu

Po-Yen Lin

Shih-Ta Chen

Ya-Ling Chiu

A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.

Growing community of inventors

Kaohsiung, Taiwan

Kang-Li Wang