Korea Atomic Energy Research Institute

Kang-Hyuk Choi

So-Young Lee

Young-Don Hong

Sun-Ju Choi

Disclosed are chelating agent-conjugated &#x3b1;-MSH peptide derivatives, preparation methods thereof, and compositions for use in a diagnosis or treatment of a melanoma tumor containing the same as an active ingredient. The novel &#x3b1;-MSH peptide derivatives conjugated with chelating agent according to the present invention are highly selective to the melanocortin-1 receptor which is &#x3b1;-MSH receptor expressing in melanoma tumor and their labeling rate of a radioactive isotope is high. Also, they remain in kidney shortly and have high taking rate of the melanoma tumor. Therefore, with the aforesaid reasons, they may be effectively used for early diagnosis or treatment of melanoma tumor.

Chelating agent conjugated &#x3b1;-MSH peptide derivatives, preparation method thereof and composition for diagnosis and treatment of melanoma comprising the same as an active ingredient

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Daejeon, South Korea

Kang-Hyuk Choi