Ono Pharmaceutical Co., Ltd.

Kaneyoshi Honjo

Narito Tateishi

Nobuo Katsube

A pharmaceutical composition for the treatment and/or prevention of cerebral ischemic diseases, which comprises two components, i.e. an astrocyte function-improving agent, preferably a compound represented by the formula (I): (wherein Ris hydroxy, etc., (1) n is 1, Ris hydrogen and Ris (alkyl of which one carbon atom is substituted by fluorine)-CH&#x2014; or (2) n is 0 or 1, Ris hydrogen, etc., and Ris alkyl, etc.) and a thrombolytic agent, preferably tissue plasminogen activator, as active ingredients. The pharmaceutical composition of the present invention exhibits a synergistic therapeutic effect compared to independent administration of an astrocyte function-improving agent and a thrombolytic agent.

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Takatsuki, Japan

Kaneyoshi Honjo