Kyowa Medex Co., Ltd.

Ciba-geigy Corporation

Janssen Pharmaceutica Nv

The United States of America As Represented by the Department of Health

Daiichi Pharmaceutical Co., Ltd.

Nisshin Flour Milling Co., Ltd.

Wakunaga Seiyaku Kabushiki Kaisha

Wakunaga Seiyaku K.k.

Kaneto Uekama

Hiroyuki Sugiuchi

Tetsumi Irie

Eiko Shutoh

Kazuhito Miyauchi

Susumu Ohsawa

Akira Miike

Toshio Tatano

Toru Fuwa

Norihiko Kayahara

Yoshiyuki Tahara

Josef Pitha

Takanori Ijitsu

Masahiko Kikuchi

Yukihiko Nagase

Akira Kondo

Fumitoshi Hirayama

Haruo Kunihiro

Yasuhiro Okamoto

Tohru Hibi

Masashi Tatsumi

Mikio Hanafusa

Mitchell Harman

Tadashi Yamada

Masaaki Ohta

Piperazine-cyclodextrin complexes

A pharmaceutical composition for trans-mucosal or transdermal administration wherein a per-C.sub.2-18 acylated cyclodextrin is used as a drug reservoir or carrier. The composition can be used safely and exhibits excellent drug release behavior.

Acylated cyclodextrin-containing pharmaceutical composition

Method for determination of cholesterol in low-density lipoprotein or

Provided is a method of determining the amount of cholesterol in high-density lipoprotein (HDL), which comprises reacting an HDL-containing sample with cholesterol esterase and cholesterol oxidase or cholesterol dehydrogenase in the presence of a reagent for aggregating lipoproteins- except HDL, and determining the amount of hydrogen peroxide or reductive co-enzyme formed therein.

Method of determining the amount of cholesterol in a high-density

Aromatic compositions which comprise perfumes included in cyclodextrins whose inclusion ability depends on a pH of a solution containing the perfumes and cyclodextrins and pH-adjusting substances whereby a release rate of the perfume can be controlled, are described. Aromatic compositions are also disclosed, which comprise perfumes coated or covered with materials whose solubility depends on the pH of a solution containing the coated perfumes, and a pH-adjusting substance to change the pH as desired. Methods for controlling the release rate of the perfumes are also described.

Aromatic composition and method for controlling aroma

Crystalline complexes of steroid hormones with gamma-cyclodextrin are prepared by mixing the components together. Tablets can be formed from the complexes, which can be administered by contact with the mucosa to provide effective transfer of the hormones into the systemic circulation, gradually eliminating the hormones therefrom.

Administration of steroid hormones

Now is provided a new sustained release drug preparation comprising such an inclusion complex of a medical compound with a hydrophobic cyclodextrin derivative, e.g. ethylated cyclodextrins, which sustains or retards the dissolution and release of the medical compound at a controlled rate from the inclusion complex and hence from the drug preparation containing the inclusion complex, so as to maintain the concentration of the medical compound in blood at an effective level for prolonged time. This drug preparation may further contain a second type of an inclusion complex of the medical compound with a hydrophilic cyclodextrin or hydrophilic cyclodextrin derivative, in mixture with the first type of the inclusion complex of the medical compound with a hydrophobic cyclodextrin derivative, to maintain the controlled release of the medical compound from the drug.

Sustained release drug preparation

The invention relates to a new medicinal composition containing .alpha.-[3-chloro-4-(3-pyrrolin-1-yl)-phenyl]-propionic acid as the pharmacologically active ingredient, having analgesic and antiinflammatory properties, which composition has markedly improved properties, particularly with respect to taste and stability.

Medicinal composition containing pirprofen and cyclodextrin and a method

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Kumamoto, Japan

Kaneto Uekama