Sankyo Company, Limited

Kaneo Ogawa

Shuji Takahashi

Masaaki Takahashi

Akio Torikata

Koichi Hirai

Takeshi Kagasaki

Yuji Iwano

Kazuhiko Tanzawa

Tsuyoshi Hosoya

Yoshiharu Sakaida

Hideyuki Shiozawa

Kentaro Kodama

Akira Ishii

Katsumi Fujimoto

Compounds of formula (I): ##STR1## (wherein R represents a hydrogen atom or an acetyl group), which we have named 'the adenophostins', and, have the ability to increase intracellular calcium ion concentrations by acting on the inositol 1,4,5-trisphosphate (InsP.sub.3) receptors which exist in the endoplasmic reticulum. The adenophostins are useful as hypertensive agents. They can be prepared by cultivation of a microorganism of the genus Penicillium, e.g. Penicillium brevicompactum SANK 11991 (FERM BP-3499) or Penicillium brevicompactum SANK 12177 (FERM BP-3500).

Adenophostins

Two thiomarinol derivatives, which have antibacterial and anti-mycoplasmal properties, are obtainable from microorganisms of the genus Alteromonas and are named 'thiomarinol B' and 'thiomarinol C'. Thiomarinol B can also be prepared by the oxidation of thiomarinol.

Thiomarinol compounds

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Iwaki, Japan

Kaneo Ogawa