Valeant Pharmaceuticals North America

Icn Pharmaceuticals, Inc.

Valeant Pharmaceuticals International

Valeant Research and Development

Ribapharm Inc.

Kanda Ramasamy

Haoyun An

Zhi Hong

Jean-Luc Girardet

Robert C Tam

Stephanie Shaw

Devron R Averett

Johnson Lau

Robert L Orr

An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.

Synthesis and use of 2'-substituted-N6-modified nucleosides

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A hydroxyalkylated heterocyclic base is prepared by reacting a heterocyclic base with an alkylene carbonate in dimethylacetamide as a solvent, wherein the hydroxyalkylated heterocyclic base is isolated from the solvent using isopropanol or tert-butylmethylether.

Synthesis for hydroxyalkylated heterocyclic bases

Novel heterocyclic aromatic compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Type 1 and Type 2 activity.

Tirazole nucleoside analogs and methods for using same

Nucleosides, novel nucleoside analog compounds and their novel prodrug forms are disclosed. The novel compounds, prodrugs, or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Type 1 and Type 2 activity.

Nucleoside compounds and uses thereof

Monocyclic L-nucleosides, analogs and uses thereof

Growing community of inventors

Aliso Viejo, CA, United States of America

Kanda Ramasamy