Council of Scientific and Industrial Research

Kanaya Lal Dhar

Ghulam Nabi Qazi

Subhash Chandra Taneja

Sukhdev Swami Handa

Om Parkash Suri

Surrinder Koul

Vijay Kumar Sethi

Randhir S Kapil

Satish Chander Puri

Geeta Handa

Rajinder Parshad

Ravi Ji Kotru

The present invention relates to the use of dihalomethanes as reagents for the preparation of Topotecan&lcub;4-(S)-10(dimethylamino)-methyl-4-ethyl 4,9 dihydroxyl-H-pyrano&lsqb;3&prime;4&prime;:6,7&rsqb;indolizino-&lsqb;1,2-b&rsqb;quinoline-3,14(4H,12H)dione&rcub; from 10-hydroxycamptothecin. The invention discloses the rationale use of dichloromethane under solid-liquid phase transfer catalysis, which can behave both as solvent and a reactant when it serves as a source for C-1 unit for amino-alkylation of 10-hydroxy-4-(S)camptothecin.

Process for preparing Topotecan from 10-hydroxy-4-(S) camptothecin

This invention discloses a process for the use of a novel organism belonging to the genus Trichosporon sp. as whole wet or dry cell culture or cell free extract or crude enzyme or pure isolated enzyme The strain of Trichosporon sp. used in the process is designated as RRLY-15 and has been deposited in Deutsche Sammlung von Mikroorganismen und Zellekulturen GmbH (DSMZ). The invention also discloses the preparation of S(&plus;)-6-methoxy-2-naphthalene acetic acid (naproxen) of formula (2) through enantioselective hydrolysis of a racemic mixture of alkyl esters of (&plusmn;)-6-methoxy-&agr;-methyl-2-naphthalene acetic acid of formula (1) where R represents &mdash;CH,,&mdash;C,H,,&mdash;C,H,,&mdash;C,H,and the like and S(&plus;)- Naproxen is a medicinally important non steroidal anti-inflammatory drug.

Trichosporon sp RRLY-15 (DSM 11829) and its use to prepare S(&plus;)-6-methoxy-methyl-2-naphthalene acetic acid

Disclosed herein is a novel fraction comprising a mixture of boswellic acids, wherein the fraction exhibits anti-inflammatory and antiulcerogenic activities. Also disclosed is a novel boswellic acid compound exhibiting anti-inflammatory, antiathritic and antiulcerogenic activities. Also disclosed is a process for isolating a boswellic acid fraction and individual boswellic acids therefrom.

Boswellic acid compositions and preparation thereof

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Jammu, India

Kanaya Lal Dhar