Eisai Company, Limited

Kaname Miyamoto

Takashi Yamanaka

Ieharu Hishinuma

Junichi Nagakawa

Naoyuki Shimomura

Tsuneo Wakabayashi

Kazuo Hirota

Toshihiko Kaneko

Shigeru Souda

Shuhei Miyazawa

Shigeki Hibi

Norihiro Ueda

Seiichiro Nomoto

Katsuya Tagami

Yasushi Okamoto

Makoto Okita

Tsutomu Kawata

Junsaku Nagaoka

Hidetoshi Kawashima

Toru Horie

Naoko Nagaoka

Makoto Ikeda

Yoshitake Ogata

Shinya Abe

Isao Yamatsu

Hiromitsu Yokohama

Tsutomu Yoshimura

Yasunori Akita

Koichi Katayama

Tohru Horie

Tetsuya Kawahara

Koukichi Harada

Masanobu Shinoda

Koichi Abe

Naoki Kobayashi

Hirotoshi Numata

A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.

Benzodioxole derivatives

A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.

Quinone derivatives and pharmacological use

The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are each a lower alkoxy group

Quinone derivatives

A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle, R2 is a substituted nitrogen containing radical wherein the substituents on said nitrogen are selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl or heterocycles, and where said nitrogen may be a ring heteroatom, and R3, R4 and R5, may be the same or different and each are hydrogen, lower alkyl or lower alkoxy groups.

Ouinone derivatives and pharmacological use

Benzodioxale derivatives

A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m --, m being an integer of 2 or 3, ##STR3## or a group of the formula:

Guanidinobenzoic ester derivative

A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m--, m being an integer of 2 or 3, ##STR3## or a group of the formula:

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Ibaraki, Japan

Kaname Miyamoto