Fuso Pharmaceutical Industries, Ltd.

Kanako Abe

Akio Matsuhisa

Hiroyuki Keshi

Hiroshi Ueyama

Masahiro Asakura

Hirotsugu Uehara

Yuichi Oku

Souji Eda

Yoshihiko Uesaka

Norihiko Sugimoto

Kazumasa Kamei

Yusuke Shibahara

Aya Keshi

Nana Sakamoto

Shiho Yamazaki

Very simple, highly sensitive detection or quantification of target nucleic acids of interest has been achieved by: hybridizing mask oligonucleotides to regions in a single-stranded region of a nucleic acid to be assayed between which a region to be hybridized by an oligonucleotide probe is positioned, thereby opening the probe-hybridizing region and keeping the single-stranded region of the target nucleic acid stable, and then subjecting this nucleic acid having the single-stranded region to nucleic acid chromatography.

Nucleic acid detection or quantification method using mask oligonucleotide, and device for same

The present invention provides antibodies that show specific reactivity to disulfide-type HMGB1. Furthermore, the present invention provides methods for specifically measuring disulfide-type HMGB1 using the antibodies, and kits or reagents for the measurement. The present invention also provides methods for measuring total HMGB1 using such an antibody and an antibody that binds to both disulfide-type HMGB1 and reduced-type HMGB1 but does not bind to des-HMGB1, and kits or reagents for the measurement.

Disulfide-type HMGB1-specific antibody, method for measuring disulfide-type HMGB1 and kit for said measurement, and measurement method capable of quantitating all of HMGB1 molecules including reduced HMGB1, disulfide-type HMGB1 and thrombin-cleavable HMGB1 and kit for said measurement

The DNA from the bacteria,is extracted, then completely digested with restriction enzyme HindIII, followed by cloning into a suitable vector to select a probe comprising DNA which is essentially contained in,then the sequence of the probe is elucidated.

Probes for the diagnosis of infections caused by bacteroides fragilis

The DNA from the bacteria,is extracted, then completely digested with restriction enzyme HindIII, followed by cloning into a suitable vector to select a probe comprising DNA which is essentially contained in,, then the sequence of the probe is elucidated.

Probes for the diagnosis of infections caused by Streptococcus pyogenes

The DNA from the bacteria,is extracted, then completely digested with restriction enzyme Hind III, followed by cloning into a suitable vector to select a probe comprising DNA which is essentially contained in,, then the sequence of the probe is elucidated.

Probes for the diagnosis of infections caused by Klebsiella pneumoniae

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Yawata, Japan

Kanako Abe