Janssen Pharmaceutica Nv

Amgen Inc.

Kanaka Pattabiraman

J Guy Breitenbucher

Wei Xiao

Richard Apodaca

Mark Seierstad

Christopher Harold Fotsch

Paul E Harrington

Sarah Lively

Pierre Deprez

David St Jean

Taoues Temal-Laib

Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase

The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes. 

Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Certain N-heteroarylpiperazinyl urea compounds of Formula (I), as defined in the specification, are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis). 

N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase

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Kanaka Pattabiraman