Pure World Botanicals, Inc.

Naturex Sa

Naturex

Impact Therapeutics, Inc.

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Kan He

Qun Yi Zheng

Bo Lin Zheng

Marc Roller

Alvin Ibarra

Jacques Dikansky

Yu Shao

Naisheng Bai

Calvin Hyungchan Kim

Minsheng Zhang

Antoine Charles Bily

Lingling Rogers

Stephen Wolthoff

Baoliang Cui

Andrew Scholey

Dong Liu

Baihua Hu

Lianshan Zhang

Val Madis

Natalie I Koether

Zhong Guan Shao

Antoine Bily

Disclosed are methods of enhancing neurocognitive function by administering of American. Preferred dosages in the range of 5 to 50 mg total ginsenosides enhance cognitive function&#x2014;including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

Application of American Ginseng to enhance neurocognitive function

The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts or prodrugs thereof, which inhibit the poly(ADP-ribose) polymerases (PARP) and therefore are useful for treating diseases, disorders, and conditions related to PARP. The present invention also discloses pharmaceutical compositions comprising a compound of formula (I), and methods of using such compounds to inhibit PARP enzymes, and to treat diseases, disorders, and conditions related to PARP. 

Quinazolinediones and their use

Disclosed are methods of alleviating oxidative stress, regulating blood glucose levels, and controlling pancreatic lipase activity by administering a Rosemary extract. Such methods may be useful to help body weight and body fat, prevent obesity, and treat hyperglycemia, hyperinsulinemia, cardiovascular disease and Type-2 diabetes. Preferred extracts contain 20% or 50% carnosic acid.

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Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function&#x2014;including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

Application of american ginseng to enhance neurocognitive function

The present invention relates to compounds represented by formula (I), which can modulate the activity of protein kinases. The invention also relates to a composition containing a compound of formula (I), and a method for synthesizing and using such compound for preventing or treating ALK or cMet mediated disorders or conditions. 

Phosphorus containing compounds as protein kinase inhibitors

Aseed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. Theseed extract includes, inter alia, an isolated compound (2S,3E,4S)2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-&#x3b2;-D-glucopyranosyl-&#x3b2;-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-&#x3b2;-D-glucopyranosyl-&#x3b2;-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.

Aseed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. Theseed extract includes, inter alia, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-&#x3b2;-D-glucopyranosyl-&#x3b2;-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-&#x3b2;-D-glucopyranosyl-&#x3b2;-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.

The invention relates to compositions that can be isolated from Lepidium plant material and to methods for their isolation. The compositions are useful for treating and preventing cancer and sexual dysfunction.

Compositions and methods for their preparation from lepidium

The present invention relates to novel imidazole alkaloid compounds that have been isolated as a form of chloride salt from a root extract ofWalp, with the common name Maca, and identified below as 1,3-bis(phenylmethyl)-4,5-dimethyl-1H-imidazlium chloride and 1,3-bis(phenylmethyl)-2,4,5-trimethyl-1H-imidazlium chloride, compounds (1) and (2), respectively.The present invention further relates to the use of these novel compounds (1) and (2) to treat proliferative diseases, such as but not limited to cancer.

Imidazole alkaloids from Lepidium meyenii and methods of usage

The present invention relates generally to the sterilization and disinfection of agricultural and botanical products such as botanical powders. More particularly, the present invention is directed towards the use of HBS technology whereby contaminated agricultural products are contacted, at ambient pressure, with an oxidant such as nascent oxygen or hydroxyl radicals thus resulting in the oxidization and destruction of the contaminating microorganisms.

Process for sterilization and disinfecting of agriculture and botanic products

An isolated composition obtained by extracting roots is provided. The composition is substantially free of cellulose and comprises between about 5% and about 9% of benzyl isothiocyanate, between about 1% and about 3% of Lepidium sterol component, between about 20% and about 30% of Lepidium fatty acid component, and about 10% or more of macamide component. The composition is prepared by a process which comprises contacting Lepidium meyenii roots with a first aqueous solvent of about 90% vol-% or more water, then separating the residual root material from the first contacted aqueous solvent, then contacting the residual root material with a second aqueous solvent which comprises a mixture of an alcohol and water having about 90 vol-% alcohol or more to form a liquor, and then finally concentrating the liquor to obtain the composition. The composition can be used for treating cancer and sexual dysfunction.

Treatment of sexual dysfunction with an extract of Lepidium meyenii roots

Provided are products including trihydroxystilbenes and glycosylated derivatives thereof. Also provided are compositions containing these products with an aqueous solvent, particularly and alcohol-water mixture, and reverse phase chromatographic methods for isolating and purifying the compositions from plant materials. The products have biological activity, including anti-tumor activity.

Products comprising trihydroxystilbenes and derivatives thereof and methods for their manufacture and use

An isolated composition obtained by extracting,roots is provided. The composition is substantially free of cellulose and comprises between about 5% and about 9% of benzyl isothiocyanate, between about 1% and about 3% of Lepidium sterol component, between about 20% and about 30% of Lepidium fatty acid component, and about 10% or more of macamide component. The composition is prepared by a process which comprises contacting,roots with a first aqueous solvent of about 90% vol-% or more water, then separating the residual,root material from the first contacted aqueous solvent, then contacting the residual,root material with a second aqueous solvent which comprises a mixture of an alcohol and water having about 90 vol-% alcohol or more to form a liquor, and then finally concentrating the liquor to obtain the composition. The composition can be used for treating cancer and sexual dysfunction.

Growing community of inventors

River Edge, NJ, United States of America

Kan He