Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Kan Chen

Lei Zhang

Weikang Tao

Lianshan Zhang

Guoqing Cao

Xin Ye

Xiangdong Qu

Jijun Yuan

Zhibin Xu

Provided is an IL-15 heterodimeric protein, such as an IL-15/IL-15R&#x3b1; heterodimeric protein. The IL-15 heterodimeric protein contains protein (I) and protein (II). Protein (I) is recombinantly produced by combining IL-15 or a variant thereof with a first Fc variant, and protein (II) is a second Fc variant, or recombinantly produced by combining IL-15R&#x3b1; or a variant thereof with a second Fc variant. The first Fc variant and the second Fc variant are preferably linked via a 'Knob-into-Hole' mode. Also provided are methods of using the IL-15 heterodimeric proteins to modulate an immune response. The provided IL-15 heterodimeric proteins have significant anti-tumor activity, better biological activity and prolonged in vivo half-life compared to the IL-15 molecule alone.

IL-15 heterodimeric protein and uses thereof

Growing community of inventors

Shanghai, China

Kan Chen