University System of Maryland

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Sarepta Therapeutics, Inc.

Progeria Research Foundation, Inc.

Magic Blue, LLC

Kan Cao

Francis S Collins

Ryszard M Kole

Michael R Erdos

Leslie B Gordon

Richard Keith Bestwick

Chandamany Arya

Jasmin El Kordi

A sunscreen composition, containing an effective amount of Methylene Blue and/or a hydrate and or a pharmaceutically-acceptable salt thereof; an effective amount of one or more UVA and/or UVB absorbing compounds, with the proviso that Oxybenzone and Octinoxate are excluded; and an excipient base.

Ingredient in sunscreen compositions

Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Oligonucleotide analogues targeting human LMNA

A method of alleviating age-related symptoms in a mammal, which comprises a step of administering to a mammal in need thereof, an effective amount of a composition containing an effective amount of at least methylene blue.

Methods of treating age-related symptoms in mammals and compositions therefor

Provided are methods of treatment in subjects having progeroid diseases and related conditions which rely upon LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA

Growing community of inventors

Bowie, MD, United States of America

Kan Cao