Warszawski Uniwersytet Medyczny

Instytut Farmaceutyczny

Siec Badawcza Lukasiewicz-Instytut Chemii Przemyslowej Imienia Profesora Ignacego Moscickiego

Kamil Jatczak

Oliwia Zegrocka-Stendel

Grzegorz Grynkiewicz

Marta Laszcz

Mariusz Marek Gruza

Marcin Cybulski

Jerzy Winiarski

Katarzyna Koziak

Piotr Cmoch

Marek Kubiszewski

Malgorzata Dutkiewicz

Marek Napiórkowski

Konrad Zielinski

Katarzyna Filip

Krzysztof Bojakowski

Lukasz Jedynak

Magdalena Kowalewska

Tomasz Giller

Dorota Maciejko

Agnieszka Burzynska-Prajzner

Katarzyna Sidoryk

Dorota Pietrzkowska

Iwona Grabowska

Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13. 

Process of vitamin Kderivatives preparation

Described herein is compound including a protoescigenin derivative having pharmacological properties. Also described are a process of its preparation, and the use of such a compound as a medicament, especially for treating vascular disorders. A pharmaceutical composition comprising such compound is further described.

Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound

A process for the preparation of protoescigenin by hydrolysis of escin isolated from. The process includes the following steps: a two-step hydrolysis first under acidic and then basic conditions, enrichment of the crude mixture of sapogenins with protoescigenin, an isolation of the mixture of sapogenins in a solid form, and a purification of the obtained solid and isolation of high purity protoescigenin. The invention also relates to protoescigenin monohydrate in a crystalline form and the preparation thereof. Protoescigenin is a polyhydroxy aglycone, which can be used as a synthon in the chemical modifications of naturally occurring saponins.

Process for the preparation of protoescigenin

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Pruszków, Poland

Kamil Jatczak