Other

The Schepens Eye Research Institute, Inc.

Vegenics Pty Limited

Ma, Jie

Lashkari, Kameran

Opthea Limited

Kameran Lashkari

Mark Harooni

Marie Shatos

Megan E Baldwin

Jie Ma

Tat Fong Ng

The present application is directed to the use of a VEGF-C inhibitor, a VEGFR-2 inhibitor and/or a VEGFR-3 inhibitor as a prophylactic or therapeutic for the treatment of eye disorders such as a maculopathy and pathogenic ocular neovascularisation. The application is also directed to the use of a VEGF-C measurement from a biological sample from a mammalian subject as a predictive marker, a selected marker, a responsive marker or a tracking marker for a disease or condition selected from the group consisting of a maculopathy and pathogenic ocular neovascularization.

Treatment for age-related macular degeneration (AMD) and pathogenic ocular neovascularization

The present application is directed to the use of a VEGF-C inhibitor, a VEGFR-2 inhibitor and/or a VEGFR-3 inhibitor as a prophylactic or therapeutic for the treatment of eye disorders such as a maculopathy and pathogenic ocular neovascularization. The application is also directed to the use of a VEGF-C measurement from a biological sample from a mammalian subject as a predictive marker, a selected marker, a responsive marker or a tracking marker for a disease or condition selected from the group consisting of a maculopathy and pathogenic ocular neovascularization.

Methods of using VEGF-C biomarkers for age-related macular degeneration (AMD) diagnosis

The invention provides compositions and methods of predicting a subject's risk of developing age-related macular degeneration (AMD) and methods of treating, delaying, or preventing the development and progression of AMD.

Methods for treatment of age-related macular degeneration

The present invention is directed to an adult retinal cell line isolated from extra-retinal ocular tissue, and methods of isolating adult retinal cells from extra-retinal ocular tissue. The present invention is further directed to adult retinal stem cells isolated from vestigial tissue dissected from the eye of a donor mammal suffering from persistent fetal vasculature. The present invention is further directed to a culture medium for growing or maintaining retinal stem cells, and methods of maintaining adult retinal cells in culture. The present invention is further directed to methods of treating a treating an eye with retinal dystrophy using retinal stem cells, and an eye with glaucomatous injury with retinal stem cells. The present invention is further directed to kits for harvesting extra-retinal ocular tissue comprising a sterile container and a harvesting solution, wherein the kit allows the survival of the tissue until later dissociation of cells from the tissue.

Isolation and therapeutic application of adult retinal stem cells collected from extra-retinal tissues

An infrared binocular indirect ophthalmoscope (iBIO) is provided to the simultaneous examination and treatment of the human eye. The iBIO operates in infrared light, at long wavelengths to penetrate the eye and image the retina. The iBIO can further include a treatment beam to activate an appropriate agent that has been injected in the human eye, for performing a treatment on the eye. The photosensitizing agent can include any photosensitive material that is activated at a predetermined wavelength. Can be useful in photodynamic therapy and other types of treatment for simultaneous examination and treatment of the human eye.

System and method for use of infrared binocular indirect ophthalmoscopes in imaging and photodynamic therapy

The present invention relates to a binocular indirect ophthalmoscope for observing and examining the fundus of the human eye. The ophthalmoscope of the invention integrates an electro-optic imaging system in the viewing optics of the ophthalmoscope. Advantageously, such integration permits the stereoscopic observation of the retina and choroid by employing radiation ranging from the near ultraviolet to the infrared, including the visible spectrum. A light source illuminates a desired portion of a patient's fundus and the radiation reflected in response to the illuminating radiation is brought to focus to produce an aerial image of the fundus. A pair of ophthalmoscope lenses then magnify and image the aerial image along two different optical paths onto imaging sensors, such as charge coupled devices (CCDs) and image cameras, or image tubes such as image intensifiers. Visible displays, such as liquid crystal displays (LCDs), cathode ray tubes (CRTs), or the fluorescent screen of the image tube, then photoelectrically convert the fundus images formed on the imaging sensors and direct corresponding visible images thereof to an observer's pupils by means of ocular lenses.

Electro-optic binocular indirect ophthalmoscope

Electro-optic binocular indirect ophthalmoscope for stereoscopic

A binocular indirect ophthalmoscope for observing and examining the fundus of the human eye is realized by integrating an electro-optic imaging system in the viewing optics of the ophthalmoscope. Advantageously, this permits the stereoscopic observation of the retina and choroid using illumination ranging from the near ultraviolet to the infrared, including the visible spectrum. A light source illuminates a desired portion of a patient's fundus with the reflected radiation brought to focus to produce an aerial image of the fundus. A pair of ophthalmoscope lenses then magnify and image the aerial image along two different optical paths onto imaging sensors, such as charge coupled devices (CCDs) and image cameras, or image tubes, such as image intensifiers. Visible displays, such as liquid crystal displays (LCDs), cathode ray tubes (CRTs), or the fluorescent screen of the image tube, then photoelectrically convert the fundus images formed on the imaging sensors and direct corresponding visible images thereof to an observer's pupils by means of ocular lenses.

Growing community of inventors

Boston, MA, United States of America

Kameran Lashkari