Pharmaquest Limited

Collegium Pharmaceutical, Inc.

Pierce Management LLC

Peirce Management, LLC

Armaquest, Inc.

Peierce Management LLC

Kamal K Midha

Mark Hirsh

Whe-Yong Lo

Martin H Teicher

Jane C Hirsh

Vijai Kumar

Hans E Junginger

Shubha Chungi

Theodore L Iorio

Hans E Junginer

New pharmaceutical compositions in unit dosage form are disclosed for both intraoral and oral administration to a patient, said unit dosage form configured to be placed intraorally of said patient, which comprises:

Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration

Novel pharmaceutical dosage forms provide for pulsatile delivery of an antiarrhythmic agent that releases the drug in spaced apart &ldquo;pulses.&rdquo; The dosage forms are comprised of first, second and optional third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads, granules, or particles or may comprise a single tablet with the first, second and optional third dosage units incorporated therein, or a &ldquo;coated core&rdquo; dosage form. Methods of treatment using the pharmaceutical dosage forms are provided as well.

Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent

Pharmaceutical composition containing two active ingredients for smoking cessation

Novel pharmaceutical dosage forms provide for pulsatile delivery of methylphenidate, i.e., release encapsulated drug in spaced apart &ldquo;pulses.&rdquo; The dosage forms are comprised of first, second and optionally third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads or particles, or may comprise a single tablet with the first, second and optionally third dosage units each representing an integral and discrete segment thereof. Methods of treatment using the pharmaceutical dosage forms are provided as well.

Pharmaceutical dosage form for pulsatile delivery of methylphenidate

A method of treating dysphoria or depression is disclosed in a patient which comprises the step of administering orally or non-orally to said patient, a therapeutically effective amount of 1-threo-methylphenidate or a pharmaceutically acceptable acid addition salt thereof.

Method of treating depression using 1-threo-methylphenidate

The invention includes a patch and method for transdermal delivery of bupropion base. In the method of this invention, a patient is administered a bupropion base in an amount effective to alleviate withdrawal symptoms and to prevent or reduce craving of nicotine in said patient. Alternatively, an effective amount of bupropion base is delivered to alleviate depression in a patient or to treat obesity. A transdermal patch includes a bupropion base. The bupropion base can be mixed with an acceptable pharmaceutical carrier.

Patch and method for transdermal delivery of bupropion base

The invention includes an apparatus and method for transdermal delivery of bupropion base. In the method of this invention, patient is administered parenterally a bupropion base in an amount effective to alleviate withdrawal symptoms and to prevent or reduce craving of nicotine in said patient. Alternatively, an effective amount of bupropion base is delivered to alleviate depression in a patient. A transdermal delivery system includes a bupropion base. The bupropion base can be mixed with an acceptable pharmaceutical carrier.

Apparatus and method for transdermal delivery of bupropion

Novel pharmaceutical dosage forms provide for pulsatile delivery of d-threo-methylphenidate and a second CNS stimulant, i.e., release encapsulated drug in spaced apart &ldquo;pulses.&rdquo; The second CNS stimulant may be an analeptic agent or a psychostimulant, with analeptic agents preferred. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads or particles, or may comprise a tablet with the first, second and optionally third dosage units each representing an integral and discrete segment thereof. Methods of treatment using the pharmaceutical dosage forms are provided as well.

Pharmaceutical dosage form for pulsatile delivery of d-threo-methylphenidate and a second CNS stimulant

A method of treating depression to elicit prompt relief from depression is disclosed. The method comprises the step of administering orally or non-orally to said patient, a therapeutically effective amount of l-threo-methylphenidate or a pharmaceutically acceptable salt thereof.

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Hamilton, Bermuda

Kamal K Midha