Tricida, Inc.

Relypsa, Inc.

Cambrios Film Solutions Corporation

Cam Holding Corporation

Renosis, Inc.

Vifor (International) Ltd.

Kalpesh N Biyani

Eric F Connor

Michael James Cope

Gerrit Klaerner

Scott M Tabakman

Jerry M Buysse

Son H Nguyen

Matthew J Kade

Randi K Gbur

Paul H Kierstead

Paul Mansky

Dominique Charmot

Yan Chen

Mingjun Liu

Futian Liu

Han-Ting Chang

Tony Kwok-Kong Mong

YongQi Mu

Scott J Hecker

Jun Shao

David E Bergbreiter

Deidre Madsen

Angela Lee

Faleh Salaymeh

Elizabeth Goka

Hongmin Zhang

Inez Lees

Jordan Kopping

Grace Huynh

Yongqi Mu

Grace Quaker

Michael A Spaid

Jeffrey A Wolk

Haixia Dai

Michael J Cope

Grace May

Xinnan Zhang

Felah Salaymeh

Jordon Kopping

Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain nonabsorbable compositions and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons, the conjugate base of a strong acid and/or a strong acid from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human.

Compositions for and methods of treating acid-base disorders

Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons and/or chloride ions from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood pH in an animal, including a human.

Proton-binding polymers for oral administration

HCl-binding compositions for and methods of treating acid-base disorders

Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of a target species from the gastrointestinal tract would provide physiological benefits.

Crosslinked poly(allylamine) polymer pharmaceutical compositions

The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal

The present disclosure is directed to a method of forming a layered structure including a nanostructure layer having nanostructures. The method includes: forming a coating layer on the surface of the nanostructure layer, reflowing the coating layer, depositing one or more conductive plugs into the coating layer, and hardening the coating layer. The one or more conductive plugs each has a first portion configured to be placed in electrical communication with the nanostructure layer and a second portion not covered by the coating layer.

Method of forming electrical contacts in layered structures

Various embodiments of the present disclosure are directed to structures comprising a nanostructure layer that includes a plurality of transparent conductors and coating layer formed on a surface thereof. In some embodiments, the coating layer includes one or more conductive plugs having outer and inner surfaces. The inner surface the plug is placed in electrical communication with the nanostructure layer and the outer surface forms conductive surface contacts proximate an outer surface of the coating layer. In some embodiments, the structure includes a polarizer and is used as a shielding layer in flat panel electrochromic displays, such as liquid crystal displays, touch panels, and the like.

Method of forming metal nanostructure-based structure

The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants

Growing community of inventors

Dublin, CA, United States of America

Kalpesh N Biyani