Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Chinoin Pharmaceutical and Chemical Works Ltd.

N-gene Research Laboratories, Inc.

N-gene Research Laboratiories Inc.

Kalman Takacs

Antal Simay

Gyula Papp

Laszlo Szekeres

Ilona Kiss Nee Ajzert

Peter Literati Nagy

Sandor Virag

Kalman Harsanyi

Pal Kiss

Eva Benedek

Ilona K Ajzert

Lajos T Nagy

Istvan Hermecz

Gabor Kovacs

Istvan Szekely

Eva Somfai

Zoltan Kapui

Gyula Sebestyen

Istvan Stadler

Bela Bertok

Antal Gajary

Jozsef Gaal

Peter L Nagy

Matyas Szentivanyi

Csaba Vertesi

Peter N Literati

Lorand Debreczeni

Janos Ori

Maria Szabo

Zsolt Bencze

Marian E Puskas

Angelika Thurna

Maria H Pap

Zoltan Sumeghy

Katalin Farago

Maria H Papp

Maria Hetyey Nee Papp

Sandor Botar

Peter S Kormoczy

Sandor J Nagy

Eva Udvardy

Jozsef Szegy

Jozsef Rimai

Mariann E Puskas

Judit Fleischer

Katalin M Kellner

Sandor Viragh

Marian Ecsery Nee Puskas

Marian Escery Nee Puskas

Sandor Bota

Iloma Kiss Nee Ajzert

Judit Szeredy Nee Varga

Iloma Kiss neAjzert

Peter Szekely Kormoczy

Judit Szeredy

The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suitable for the treatment of a state connected with oxygen deficit and/or energy deficit, or a disease based on PARP inhibition, especially an autoimmune or neurodegenerative disease, and/or a viral disease, and/or a disease caused by a toxic effect.

Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same

A pure crystalline O-(2-hydroxy-3-piperidino-1-propyl) nicotinic acid amidoxime base of the Formula (Ib) ##STR1## is disclosed characterized by a melting point of 70.degree. to 73.degree. C., giving, when dissolved in an amount of 1 to 10 ml of concentrated sulfuric acid, a yellow homogeneous solution, and showing the following spectral characteristics:

Highly pure amidoximes

The invention relates to novel compounds of the general formula (I), ##STR1## The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an antiinflammatory effect. Thus, these compounds can therapeutically be used as bronchodilators as well as antiallergic or antiinflammatory drugs, particularly in the treatment of bronchial asthma.

Process for preparing isoquinoline compounds

The invention relates to novel compounds of the general formula (I), ##STR1## wherein R means hydrogen or a straight or branched chain C.sub.1-6 alkoxy group;

Isoquinoline compounds, compositions and use

Process for the preparation of 3,4-dihydroisoquinoline

The invention concerns new sulfur-containing isoquinoline derivatives. More particularly, the invention relates to isoquinoline derivatives of the general formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,

Sulfur-containing isoquinoline derivatives in pharmaceutical

Isoquinolines are disclosed of the formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,

Sulfur-containing isoquinoline derivatives, process for the preparation

The invention concerns new compounds of the formula (I) ##STR1## wherein R.sup.1 is hydrogen, phenyl or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro;

1,2,4-Oxadiazolin-5-one derivatives, process for their preparation and

The invention concerns new compounds of the general formula (I) ##STR1## wherein R.sup.1 is hydrogen or phenyl optionally substituted by one or more of the following substituents: alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro;

1,2,4-Oxadiazine derivatives, process for their preparation and

A compound effective in the treatment of diabetic angiopathy, i.e. a selective .beta.-receptor blocker has the formula ##STR1## wherein: R.sup.2 is a hydrogen or alkyl having one to five carbon atoms,

O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the

A compound effective in the treatment of diabetic angiopathy, i.e. a selective .beta.-receptor blocker has the formula ##STR1## wherein: R.sup.2 is a hydrogen or alkyl having one to five carbon atoms, R.sup.3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl, or R.sup.2 and R.sup.3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring, preferably phenyl, naphthyl, quinolyl, isoquinolyl, pyridyl, pyrazolyl, R.sup.5 is hydrogen or alkyl having one to four carbon atoms, cycloalkyl or phenyl optionally substituted with halogen, alkoxy having one to four carbon atoms or alkyl having one to four carbon atoms, R.sup.6 is hydrogen, alkyl having one to four carbon atoms or phenyl, m=0, 1 or 2, and n=0, 1 or 2.

New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the

The invention relates to new thiazoloisoquinolines of the formula (I), or pharmaceutically acceptable salts thereof, ##STR1## wherein R.sup.1 is hydrogen, hydroxy, alkoxy or aralkoxy,

Thiazoloisoquinolines with coronary and respiratory effects

1-Cyano-2-imino-2H,4H-5,6-dihydro-8,9-dimethoxy-1,2-thiazolo(3,2a)isoquinol ine or 2-imino-2H,4H-5,6-dihydro-8,9-dimethoxy-1,2-thiazolo(3,2a)isoquinoline or a pharmaceutically acceptable salt thereof. These compounds are effective as heart medicines and respiratory analeptics.

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Budapest, Hungary

Kalman Takacs