Other

Formatech, Inc.

Windgap Medical, Inc.

Curirx Inc.

Curioralrx, LLC

The Broad Institute, Inc.

Javeri, Indu

Kaliappanadar Nellaiappan

Indu Javeri

Benjamin S Isaacs

Indu Isaacs

John G Augustine

Brent Alan Buchine

Adam R Standley

Edward F Fritsch

Bharat Dixit

Indu J Isaacs Isaacs

Formulations containing pH-sensitive nanoparticles for the enteric delivery of therapeutic agents are provided. The nanoparticles include a pH-sensitive polymer that protects the therapeutic agent against degradation in the stomach and allows it to be released in the small intestine or colon. The nanoparticle formulation is particularly effective at protecting sensitive biotherapeutic agents from degradation when administered orally, and makes it possible to avoid administration of such agents by injection. Also provided are methods for producing the formulations, as well as methods of treating diseases employing the formulations.

Formulations for enteric delivery of therapeutic agents

The invention provides pharmaceutical compositions comprising a dry medicament. The dry medicaments can be rapidly dissolved, solubilized, and/or reconstituted to deliver to a subject. The present invention provides methods of preparing a medical solution. The medical solution can be prepared from mixing the pharmaceutical composition as described herein with a first liquid.

Method and compositions for dissolving or solubilizing therapeutic agents

Provided herein are methods for preparing liposomes and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents, proteins, and/or inorganic salts in the process. In certain embodiments, the liposomal preparation contains one or more active agents. In certain embodiments, the liposomal preparations are used in the treatment of diseases or disorders.

Methods for the preparation of liposomes

Provided herein are methods for preparing liposomes comprising docetaxel and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents, proteins, and/or inorganic salts in the process. In certain embodiments, the liposomal preparations are used in the treatment of diseases or disorders.

Methods for the preparation of liposomes comprising drugs

Methods for the preparation of liposomes comprising docetaxel

This invention concerns novel methods of enhancing the solubility of a compound. Compositions prepared using such methods are also disclosed. Compositions prepared using the methods have various advantages over conventionally known compositions.

Pharmaceutical compositions of hydrophobic compounds

Methods of enhancing solubility of agents

Methods of enhancing solubility of compounds

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Lexington, MA, United States of America

Kaliappanadar Nellaiappan