Kaneka Corporation

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Kaku Nakagawa

Mikio Kitahara

Tatsumasa Mae

Misuzu Tsukagawa

Minpei Kuroda

Yoshihiro Mimaki

Yutaka Sashida

Yasuyoshi Ueda

Shiro Kitamura

Hideyuki Kishida

Mitsuaki Kitano

Kiyoshi Watanabe

Hajime Kawaharada

Takashi Asahi

Hideo Niwa

Tetsu Kakutani

Hiroyuki Maruyama

Keiji Matsumoto

Shinichi Yokota

Katsuhiro Shinjo

A composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.

Compositions for preventing or ameliorating multiple risk factor syndromes

The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

Peroxisome proliferator activated receptor ligand and process for producing the same

The object of the present invention is to provide PPAR&#x3b3; ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPAR&#x3b3; ligand as an active agent. The present invention relates to a ligand for peroxisome proliferator-activated receptor The composition according to the present invention, which comprises the PPAR&#x3b3; ligand as an active agent is useful for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity.

Ligand for peroxisome proliferator-activated receptor

A DNA sequence on which a chromosomal DNA sequence coding for human interferon-.gamma. (HuIFN-.gamma.) and having a TATA box is ligated to a sequence of a promoter. Cell cultures transformed with said DNA revealed a higher expression of HuIFN- than cell cultures transformed with a DNA which does not have such TATA box. When transformed with said DNA, cell cultures produced HuIFN-.gamma. in a serum free medium. Transformed cell cultures derived from blood cells of HuIFN-.gamma. resistant human cell-line also could produce HuIFN-.gamma..

Human interferon-gamma

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Kyoto, Japan

Kaku Nakagawa