Other

Robugen Gmbh, Pharmazeutische Fabrik

Carlbiotech, Ltd.

Kailash K Gauri

Fred Widmer

Aasmul-Olsen Stig

Klaus Pressler

Klaus-Dirk Schenk

Small peptidic compounds useful for the treatment of glaucoma

Membrane preparation and process for separating the dissolved and

Process for the preparation of protein hydrolysate and medicaments

Compositions for increasing oxygen supply in tissue of warm-blooded animals comprising at least one vasoactive compound selected from the group consisting of (a) calcium 2,5-dihydroxy-phenylsulfonate, (b) a 3,7-dihydro-3,7-dialkyl-1H-purine-2,6-dione of the formula ##STR1## wherein AlK and AlK' are individually alkyl of 1 to 4 carbon atoms, n is an integer from 2 to 4 and R is selected from the group consisting of ##STR2## and --CH.sub.2 --CH.sub.3, (c) a pyrazolo-[3,4-d]pyrimidine of the formula ##STR3## wherein R.sup.1 and R.sup.2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms and alkylcarbonylalkyl of 4 to 8 carbon atoms with the proviso that R.sup.1 and R.sup.2 are not both hydrogen and A is selected from the group consisting of ##STR4## wherein R.sup.3 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R.sup.4 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and alkenyl of 2 to 6 carbon atoms, (d) a pyridone of the formula ##STR5## wherein m is an integer from 2 to 4 and R.sup.5 is selected from the group consisting of ##STR6## --CH.sub.2 --CH.sub.3 and --CH.sub.2 --CH.sub.2 --OH and (e) a compound selected from the group consisting of nicergoline, vincamine and dipyridamol and a potentiating amount of a dialyzed concentrate of deproteinized calf's blood with the blood constituents having a molecular weight less than 10,000 and method for increasing oxygen supply to animal tissues.

Pharmaceutical composition

Herpes virus was doubly mutated in two steps by treatment with phosphono formic acid and 5-ethyl-2'-desoxyuredine. In this way the pathogenicity of the herpes virus was so weakened that they are usable as vaccines.

Process for the production of new mutants of herpes simplex virus type 1

Novel 5-lower alkyl-2'-desoxyuridine-5'-monophosphates of the formula ##STR1## wherein R is lower alkyl of 2 to 6 carbon atoms having antiviral activity.

Novel monophosphates

Uracil derivatives having the general formula: ##STR1## wherein R.sub.1 and R.sub.3 are each an alkyl group of 2 to 10 carbon atoms or an alkenyl group of 3 to 10 carbon atoms, R.sub.5 is an alkyl group of 2 to 5 carbon atoms and X is a hydrogen or halogen atom. These compounds are characterized by their fungicidal activity.

Growing community of inventors

Lentfohrden, Germany

Kailash K Gauri