Mercian Corporation

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Sanraku Incorporated

Kaichiro Kominato

Takeo Yoshioka

Rokuro Okamoto

Hiroshi Tone

Masataka Shirai

Hiroshi Tanaka

Shin-ichi Hirano

Hiroshi Iguchi

Sumio Umezawa

Yasuo Fukagawa

Toshiaki Miyake

Osamu Tsuchiya

Norio Shibamoto

Naoki Matsumoto

Yoshio Watanabe

Naoki Agata

Azuma Watanabe

Tomio Takeuchi

Shunji Kageyama

Hiroshi Nishida

Hiroyuki Chiba

Kohki Kiyoshima

Tomoyuki Kioka

Yutaka Hara

Reijko Yamamoto

Yasuo Okajima

3,4'-dideoxymycaminosltylonolide derivative and process for producing

4-Hydroxypyridine derivative represented by the following formula ##STR1## wherein R represents a methyl group or an isopropyl group, and the method for preparing the derivative comprising the step of cultivating a strain belonging to Streptomyces karnatakensis are disclosed. Also disclosed are the pharmaceutical composition comprising the same and a method for treating circulatory diseases comprising the step of administering said compound to a patient.

4-hydroxypyridine derivatives, useful for treating circulatory diseases

Adriamycin derivatives represented by formula (I) ##STR1## wherein R denotes a divalent hydrocarbon group,

Conjugate of adriamycin and cyclodextrin

Tylosin derivatives represented by the following general formula (I): ##STR1## [wherein R denotes a hydrogen atom, acetyl, propionyl or a radical of Si(R.sup.2).sub.3 (in which R.sup.2 is a lower alkyl group), and R.sup.1 stands for a hydrogen atom or a radical of Si(R.sup.2 .sub.3 ] are useful as intermediates for the synthesis of 4'-acyl derivatives of tylosin because, after introduction of any desired acyl group at the 4'-hydroxyl group, the silyl protective group can be readily removed without liberation of the acyl group. This invention also provides processes for producing the tylosin derivatives. More specifically, it provides a melthod of selectively protecting 2'- and 4''-hydroxyl groups of tylosin (those of higher reactivity among the hydroxyl groups involved); a method of selectively protecting only the 4''-hydroxyl group of tylosin; a method of selectively protecting the 3- and 4''-hydroxyl groups of 2'-O-acyltylosin; and a method of protecting 3-, 2'- and 4''-hydroxyl groups of tylosin.

Tylosin derivatives and processes for producing the same

Growing community of inventors

Yamato, Japan

Kaichiro Kominato