Alibaba Group Holding Limited

Zhejiang University

Chengdu Monolithic Power Systems Co., Ltd.

Advanced New Technologies Co., Ltd.

Kai Wang

Yuan Chen

Naixing Kuang

Yayang Guan

Fang Wang

Hong Yuan

Fuqiang Hu

Yunchang Wu

Lijuan Wen

Tingting Meng

Qiming Zhao

Limin Qiu

Tao Wei

Xiaoqin Zhi

Shiran Bao

The present invention discloses a hydrogen or helium throttling liquefaction system using direct current (DC) flow from the cold and hot ends of the regenerative cryocoolers, which belongs to the technical field of refrigeration and cryogenics. It includes a regenerative cryocooler module, a hot-end DC flow module, a cold-end DC flow module, a throttling liquefaction module, and a gas-phase circulation module. The modules are interconnected to form a closed loop for the flow of hydrogen or helium working fluid. DC flow is introduced from the cold and hot ends of the regenerative cryocooler through the DC flow pipelines and DC flow valves. The hot-end DC flow exchanges heat with the reflowing low-temperature working fluid and is cooled down. After that, it mixes with the cold-end DC flow and enters the throttling liquefaction module to generate liquid phase through throttling and liquefaction. After the liquid phase has output cooling capacity, it flows through the gas-phase circulation module and then enters the back-pressure chamber of the compressor to complete the cycle. Compared with the existing small-scale hydrogen and helium liquefaction technology using regenerative cryocoolers, the present invention has the advantages of simple structure, easy installation, high heat transfer efficiency and liquefaction efficiency of the system.

Hydrogen or helium throttling liquefaction system using direct current flow from the cold and hot ends of the regenerative cryocoolers

The present invention relates to a use of Axitinib and analogs thereof in the preparation of a blood-brain barrier permeability regulator. The blood-brain barrier permeability regulator can reduce blood-brain barrier permeability, and promote recovery of a blood-brain barrier function from a pathologically impaired state to a state close to a physiological barrier. Axitinib and an analog thereof reduce blood-brain barrier permeability by inhibiting the vascular endothelial cell growth factor-phosphatidylinositol kinase-protein kinase B signaling pathway and reducing the degree to which a blood-brain barrier tight junction protein Claudin-5/Occludin is down-regulated. The blood-brain barrier permeability regulator can be used in the treatment of a disease related to causing a change in blood-brain barrier permeability.

Use of Axitinib and analogs thereof in preparing blood-brain barrier permeability regulator

The present invention relates to use of SC79 or an analogue thereof in the preparation of a blood-brain barrier permeability regulator. The blood-brain barrier permeability regulator comprises SC79 or an analogue thereof as an active ingredient, which down-regulates expression of tight junction proteins Claudin-5 and Occludin by activating Claudin-5 and Occludin signaling pathway downstream the protein kinase B, and thereby increases the blood-brain barrier permeability, and enhances the efficiency of transportation of a brain targeting drug delivery system, especially, an Angiopep-2-modified glycolipid nano-delivery system, into the brain. The present invention also relates to a kit comprising the blood-brain barrier permeability regulator and a brain targeting drug delivery system. According to the present invention, use of the blood-brain barrier permeability regulator in combination with a brain targeting drug delivery system can enhance the efficiency of transportation of a brain targeting drug delivery system into the brain, and thereby improve the therapeutic efficacy of the brain targeting drug delivery system.

Blood-brain barrier permeability regulator and use thereof

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for updating data in blockchain are provided. One of the methods includes: obtaining one or more requests for updating a plurality of pieces of data in one or more blockchains and updating the plurality of pieces of data in the one or more blockchains.

System and method for updating data in blockchain

The present disclosure provides techniques for data processing. These techniques may transport, by a computing device, individual retrieving requests for second data corresponding to a first client that sends the retrieving requests for first data into the order pool. The computing device may calculate an initial value of a second total amount of the second data, and then notify a platform of a third party to send the corresponding first data to the first client. The computing device may determine corresponding qualification after retrieving requests for the second data in the order pool are changed. The computing device may return third data to a data processing server of the third party in response to qualification determination. These techniques reduce usage of network resource and therefore increase efficacy of the networking.

Data processing method and system

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for blockchain address mapping are provided. One of the methods includes: obtaining one or more requests for creating a plurality of blockchain addresses in association with one or more local accounts; and creating the plurality of blockchain addresses respectively in association with the one or more local accounts.

System and method for blockchain address mapping

A two-channel LED driver with short circuit protection is discussed. A short process circuit monitors a short condition of the LED driver, and locks the short status if short circuit occurs at either one of or both of the channels.

Two-channel LED driver with short circuit protection and short circuit protection method for two-channel LED driver

A LED driver adopts one power stage to provide a constant drive current to drive a load, and to provide different power supply voltages to power a smart module according to a dimming signal input by users through the smart module. The LED driver provides high performance with simple circuit structure.

Smart LED driver and LED drive method

A two-channel LED driver adopts one power stage to provide a constant drive current to drive a first channel LED and a second channel LED, and to provide a power supply voltages to power a smart module. The two-channel LED driver controls the total current flowing through the first channel LED and the second channel LED according to a first dimming signal input by users through the smart module, and controls the dimming ratio between the two channels according to a second dimming signal. The two-channel LED driver provides high performance with simple circuit structure.

Growing community of inventors

Hangzhou, China

Kai Wang