Versitech, Inc.

Emv Enhance (hk) Limited

Kai Wang Kelvin To

Johnson Yiu-Nam Lau

Kwok Yung Yuen

Fan Ngai Hung

Jinxia Zhang

Fuk Woo Jasper Chan

Shuofeng Yuan

Kwok-Yung Yuen

Jie Zhou

Miltefosine is utilized to enhance immune response to vaccination, for example an influenza and/or coronavirus vaccination. The inventive subject matter also provides compositions and methods for enhancing viral yield in cultured cells, by application of a cannabinoid receptor agonist (such as methanandamide) to such cells. Such enhanced viral yield can be used to enhance virus production for purposes of vaccine formulation and/or to improve sensitivity of cell-based virus assays.

Compositions and methods for enhancing immune response to vaccination and improving vaccine production

Compositions and methods are described that provide prognostic determination of the severity of influenza infection based on the PDE3A status of an individual. Impaired PDE3A function is associated with severe symptoms on contracting influenza. Specific SNP mutations are identified that are associated with impaired PDE3A function, and primers and kits are provided that permit identification of these SNPs. Such information can also be combined with other patient data.

Compositions and methods for providing a prognosis for influenza infection

Compositions and methods are described in which the topical application of a toll-like receptor 7 agonist or a toll-like receptor 9 agonist at or near a subdermal vaccination site provides an enhanced response to the vaccination. The enhanced response can be an elevated antibody titer relative to an untreated but vaccinated subject, and/or development of cross-species immunity to species not present in the vaccinating composition.

Methods and compositions for enhancing immune response to vaccination

Growing community of inventors

Hong Kong, China

Kai Wang Kelvin To