Seattle Biomedical Research Institute

Ruprecht-karls-universitat Heidelberg

Walter and Eliza Hall Institute of Medical Research

Kai-Uwe C Matuschewski

Stefan H I Kappe

Ann-Kristin Mueller

Alan E Cowman

Alexander Gerd Maier

Kelley Van Buskirk

Mehdi Labaied

Ahmed Sayed Ibrahim Aly

Method for inoculating a vertebrate host against malaria, by administering to the host a liveorganism that is genetically engineered to disrupt a liver-stage-specific gene function.

Live genetically attenuated malaria vaccine

The invention provides methods for inducing an immune response in a vertebrate host against a protozoan parasite, comprising administering to the host a live protozoan parasite that is genetically engineered to disrupt a stage-specific gene function that is required by the protozoan parasite to establish a secondary infection in the vertebrate host. Representative protozoan parasites belong to the phyla Apicomplexa and Kinetoplastida. The vertebrate host may be a mammal or a bird.

Live genetically engineered protozoan vaccine

Method for inoculating a vertebrate host against malaria, by administering to the host a liveorganism that is genetically engineered to disrupt a gene whose expression is up-regulated in liver stage parasites and whose function is not required for entry into hose hepatocytes.

Growing community of inventors

Heidelberg, Germany

Kai-Uwe C Matuschewski