US Government As Represented by the Secretary of the Army

Kai P Leung

Sean P Concannon

A layered composite for scar treatment and prevention, the layered composite including a backing section; a drug matrix section; and a skin-interfacing section. The drug matrix section may be disposed between the back section and the skin-interfacing section. The drug matrix section may include pirfenidone in an amount of from about 1 to about 20 mg/cm. The layered composite may provide greater than about 75% release of the pirfenidone over a period of about 48 to 72 hours. A method for scar treatment and prevention that includes applying a layered composite as described to a burn wound.

Layered composite for scar treatment and prevention

A method for promoting oral hygiene that treats mature biofilms comprises the step of applying the antimicrobial peptide KSL and a surface active agent to the oral environment of applying KSL after mechanical disruption of the biofilm. An antiplaque chewing gum comprising KSL provides a sustained release oral hygiene treatment.

Antimicrobial decapeptide oral hygiene treatment

A method of preventing biofilm formation in an environment including the steps of administering to the environment an effective amount of a peptide having the amino acid sequence NH-lys-lys-val-val-phe-lys-val-lys-phe-lys-CONH[SEQ ID NO: 1] The method is useful in preventing the formation of biofilms in various environments including a home, workplace, laboratory, industrial environment, aquatic environment, animal body or human body. A method of inhibiting the growth of oral microorganisms including the steps of administering to an oral environment an effective amount of a peptide having the amino acid sequence NH-lys-val-val-phe-lys-val-lys-phe-lys-CONH[SEQ ID NO: 1].

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Libertyville, IL, United States of America

Kai P Leung