Other

Institut Fur Diagnostikforschung Gmbh an Der Freien Universitat Berlin

Schering Aktiengesellschaft

Institut Fur Diagnostikforschung Gmbh

Fuji Photo Film Company, Limited

Bayer Schering Pharma Ag

Mivenion Gmbh

Institute Fuer Diagnostik Forschung

Institut Fur Diagnosikforschung Gmbh

Freien Universitat Berlin

Insitut F&uuml;r Diagnostikforschung Gmbh

Institute for Diagnostic Research Gmbh of the Free University of Berlin

Der Freien Universitat Berlin

Morphosys Ag

Visen Medical, Inc.

Kai Licha

Wolfhard Semmler

Ulrich Speck

Christoph-Stephan Hilger

Andreas Becker

Johannes Platzek

Hiroshi Kitaguchi

Andreas Menrad

Björn Riefke

Michael Schirner

Carsten Hessenius

Rudolf Volkmer-Engert

Bj&ouml;rn Riefke

Jens Schneider-Mergner

Bertram Wiedenmann

Kazuhiro Aikawa

Masayuki Kawakami

Axel Vater

Dieter Heldmann

Rainer Haag

Jonathan Turner

Wolfgang Wrasidlo

Marie Weinhart

Hiroaki Eguchi

Florian Paulus

Bjoern Riefke

Malte Bahner

Sonja Vollmer

Violetta Sudmann

Werner Weitschiess

Christin Perlitz

Thomas Dyrks

Natsuko Tsuda

Bodo Brocks

Pia Welker

Martin Pessel

Cornelia Hanel

Stefanie Urlinger

The present invention relates to novel dendrimer conjugates, methods for their preparation and their use for treatment of diseases. The invention discloses a new method for the delivery of dendrimer conjugates with therapeutically active molecules into the cell by utilizing transmembrane solute carrier proteins enabling uptake of the inventive dendrimer conjugates. Particular subject-matter of the present invention is a conjugate of the formula E-[G-L-D(OSOM)], wherein E is a therapeutic or diagnostic effector molecule, wherein D(OSOM)is a dendrimer D carrying a number n of sulfate groups OSOM, wherein the number n of sulfate groups is selected from 6 to 96, wherein M is a cationic inorganic or organic counter ion to the anionic sulfate group, wherein L is a linker or spacer between D and E, wherein G is a connecting functional group forming the attachment between L and E, and wherein m is an integer from 1 to 20.

Therapeutic conjugates with sulfated dendrimers for intracellular targeting

The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.

Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis

The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out the method of diagnosing.

Optical imaging of rheumatoid arthritis

This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.

Near infrared imaging agent

A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, R, and Rrepresent a C-Calkyl group or the like; R, R, R, R, R, R, R, and Rrepresent a hydrogen atom, a C-Calkyl group, an aryl group or the like; Xand Xrepresent a C-Calkyl group or an aryl group and Xand Xin total have 0 to 4 carboxyl groups; m, m, and mrepresents 0 or 1; Lto Lindependently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.

Near infrared fluorescent contrast agent and method for fluorescence imaging

In-vivo diagnostic method by near infrared radiation

The description herein includes cyanine dyes and analogs of the vaso-active intestinal peptide. These are useful to provide peptide-dye conjugates for use as contrast media in optical diagnoses.

Short-warp peptide-dye conjugate as contrast agent for optical diagnostic

In-vivo diagnostic method by means of near infrared radiation

The invention relates to compounds for tumor diagnosis that consist of conjugates of dyes with short-chain peptides, which are derived from vaso-active intestinal peptide, somatostatin or neurotensin, the use of these compounds as optical dignostic agents, and diagnostic agents that contain these compounds.

Short-chain peptide-dye conjugates as contrast media for optical diagnosis

The invention relates to acid-labile and enzymatically divisible compounds for in-vivo and in-vitro diagnosis by means of near infrared radiation (NIR-radiation), the use of said compounds as optic diagnostic and therapeutic agents, and the diagnostic agents containing said compounds.

Acid-labile and enzymatically divisible dye compounds for diagnosis with near infrared light and for therapy

This invention describes galenical formulations that contain perfluoroalkyl-containing dye molecules and other perfluoroalkyl-containing substances. The new formulations are suitable as, i.a., contrast media for near-infrared diagnosis.

Perfluoro-alkyl containing dye molecules and galencial formulations

The invention relates to compounds of formula (I): F,(&mdash;A1)(&mdash;B,)(&mdash;W,) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600-1200 nm; A is a &bgr;-amyloid plaque binding biomolecule; B is a &bgr;-amyloid plaque binding colorant; and W is a &bgr;-amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo an din vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a constrasting agent in fluoresecence and transillumination diagnosis in the NIR range. Diagnostic agents containing said componenets are also disclosed.

Optical diagnostic agents for diagnosis of neurodegenerative diseases by means of near infrared radiation (NIR radiation)

This invention relates to colloidal systems charged with polymethine dyes and having suitable photophysical and pharmacological properties, their use as a contrast medium in fluorescence and transillumination diagnostics in the near infrared spectral range, as well as methods for their production.

Contrast medium for near infrared diagnosis

Growing community of inventors

Falkensee, Germany

Kai Licha