Merck Patent Gmbh

Merck Patent Gesellschaft

Kai Fabian

Hanns Wurziger

Norbert Schwesinger

Joachim Kralik

Joeran Stoldt

Steffen Enke

Herbert Tilly

Christoph Mürmann

Claus-Peter Niesert

Karl-Heinz Glüsenkamp

Norbert Schweickert

The invention relates to monoalkylaminoketones of the formula (I), in which Rand Rhave the meanings indicated. 

Method for the production of monoalkylamino ketones

A process for the enantioselective preparation of amino alcohols of formula I by enantioselective hydrogenation of amino ketones of the formula II in the presence of a non-racemic catalyst. The catalyst is a transition-metal complex in which the transition metal is complexed to a chiral diphosphine ligand.

Process for the enantioselective hydrogenation of amino alcohols

The present invention relates to processes for the bromination of organic compounds, and to bromination microreactors for carrying out these processes.

Method for brominating organic compounds

The present invention relates to a novel process for the nitration of organic compounds, preferably of aromatic and heteroaromatic compounds, using nitrating reagents which are known from the literature and new types of nitrating reagents.

Nitration in a static micromixer

The invention relates to a method for the production of trifluoroethoxy-substituted benzoic acids, by reaction of a corresponding halogenated benzoic acid with trifluoroethanol in the solvent tetrahydrofuran, in the presence of a base and a copper salt, followed by an acidic work-up.

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Wilhelmsfeld, Germany

Kai Fabian