University of California

National Technology & Engineering Solutions of Sandia, LLC

Sloan-kettering Institute for Cancer Research

Kai Deng

Trent Russell Northen

Anup Kumar Singh

Seema Singh

Govind Ragupathi

Todd A Duncombe

Xiaoliang Cheng

Wolfgang E Reindl

Disclosed herein are methods for tracking solutions, (e.g., reaction conditions in solutions). In some embodiments, the method comprises: contacting a first lanthanide-chelator complex to a first solution to generate a first barcoded solution, wherein the first lanthanide-chelator complex comprises a first lanthanide chelated by a first chelator; contacting a second lanthanide-chelator complex to a second solution to generate a second barcoded solution, wherein the second lanthanide-chelator complex comprises a second lanthanide chelated by a second chelator; mixing the first barcoded solution and the second barcoded solution to form one or more mixtures; and identifying the first lanthanide ions in the mass spectrum and the second lanthanide ions in the mass spectrum to track the condition of each of the one or more mixtures.

Lanthanide-chelator combinatorial barcoding

A method for rapid, high throughput screening of the activities of enzymes, especially ligninases and its enzyme cocktails, using nanostructure initiator mass spectrometry (NIMS) surfaces, substrates and methodology.

Determination of ligninases activities by nano-structure initiator mass spectrometry

Disclosed herein are methods, compositions and systems for analyzing and detecting enzyme activity. For examples, methods, compositions and systems for parallel detection and analysis of enzymatic activities of enzymes in complex biological mixtures are provided.

Multiplexed screening of enzyme activities using nanostructure-initiator mass spectrometry

Growing community of inventors

Orinda, CA, United States of America

Kai Deng