Sanraku-ocean Co., Ltd.

Panlabs, Inc.

Sanraku Incorporated

Kageaki Kouno

Tomoyuki Ishikura

Kazuhiko Okamura

Yasushi Okumura

Joseph Lein

Yasuo Fukagawa

Hamao Umezawa

Tomio Takeuchi

Taiji Inui

Akihiro Yoshimoto

Yasuo Fugakawa

Toshikazu Oki

Takeo Yoshioka

Rokuro Okamoto

Yasutaka Shimauchi

Mitsuyasu Okabe

Shoji Hirata

Yoshiaki Yagi

Hiroyasu Tobe

Yukio Takatsuki

This invention is to provide a new microbial process for producing daunomycin by a mutant strain belonging to the genus Streptomyces.

Process for producing daunomycin

A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.

Antibiotics, neoviridogriseins, and their method of production

A compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or a methyl group,

Antibiotics and process for production thereof

A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, --OH or --OSO.sub.3 H, and R.sub.2 represents a hydrogen atom or an unsubstituted or substituted benzyl group; and a salt thereof; processes for production thereof by fermentation; and uses thereof as antimicrobial agents.

Novel .beta.-lactam compounds, process for producing thereof, and use

New anthracycline compounds, 2-hydroxyaclacinomycin A having potent antitumor activity and lower toxicity, 2-hydroxyaklavinone as an useful precursor for producing anthracycline glycosides, and a process for the production thereof by microbial conversion method are disclosed.

2-Hydroxyaclacinomycin A and 2-hydroxyaklavinone and process for

A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl, and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.

Antibiotics and derivatives thereof having .beta.-lactamase inhibitory

Streptomyces culture

The invention is to provide a new process for producing daunomycin and baumycins having potent antitumor activity and low toxicity by microbial conversion of anthracyclinones such as aklavinone and .epsilon.-rhodomycinone.

Process for producing anthracycline glycosides

A novel antibiotic substance and derivatives thereof, having strong antibiotic activity and .beta.-lactamase inhibiting effect and a method for producing the same by aerobic cultivation of Streptomyces A 271.

Antibiotic PS-5 and derivatives having .beta.-lactamase inhibitory

A process for producing cyclodextrins which comprises using cultured medium of the strains belonging to genus Micrococcus, filtrate thereof or enzyme preparation obtained therefrom, especially, the process in which the ratio of .alpha.-cyclodextrin to .beta.-cyclodextrin can be desirably varied by regulating the condition of the reaction mixture, is disclosed.

Growing community of inventors

Tokyo, Japan

Kageaki Kouno