M. Technique Company, Ltd.

Kaeko Araki

Masakazu Enomura

Daisuke Honda

Masaki Maekawa

Jun Kuraki

Mai Yoshizumi

Shiho Aoyagi

Masahito Niikawa

Hideyuki Oka

The present application provides a microsphere comprising a lactic acid-glycolic acid copolymer (PLGA) or polylactide (PLA) as a main component, in which a biologically active substance is uniformly dispersed, wherein an average volume-based particle diameter of the microsphere is 1 μm or more and 150 μm or less, and a variation coefficient of area ratios in six regions is 0.35 or less, wherein the area ratios in six regions are calculated by (s/A)×100 (%) wherein the six regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the biologically active substance in the microsphere or a higher magnification; and dividing the electron microscope observation image into six regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the biologically active substance included in the respective divided region. The microsphere of the present invention can appropriately control the initial release amount of the biologically active substance and its release rate during a subsequent release period, and can continuously release the biologically active substance in vivo for a predetermined period of time.

Method of producing a microsphere comprising PLGA or PLA in which a biologically active substance is uniformly dispersed

Provided are a method for producing organic material microparticles and a method for modifying organic material microparticles, whereby it becomes possible to improve the crystallinity of organic material microparticles or achieve the crystal transformation of the organic material microparticles while preventing the growth of the organic material microparticles in a solvent. A surfactant is added to a solvent that is capable of partially dissolving organic material microparticles, and then the organic material microparticles are reacted with the solvent. In this manner, it becomes possible to improve the degree of crystallization of the organic material microparticles or achieve the crystal transformation of the organic material microparticles without substantially altering the particle diameters of the organic material microparticles.

Method for producing organic material microparticles, and method for modifying organic material microparticles

The present application provides a microsphere in which a main agent is uniformly dispersed in a polymer matrix, wherein an average volume-based particle diameter of the microsphere is 1 &#x3bc;m or more and 150 &#x3bc;m or less, and a variation coefficient of area ratios in four regions is 0.35 or less, wherein the area ratios in four regions are calculated by (s/A)&#xd7;100(%) wherein the four regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the main agent in the microsphere or a higher magnification; and dividing the electron microscope observation image into four regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the main agent included in the respective divided region. The microsphere of the present invention can appropriately control the initial release amount of the main agent and its release rate during a subsequent release period, and can continuously release the main agent for a predetermined period of time.

Main agent uniformly dispersed microsphere and a sustained release formulation comprising the same

Provided are an immediately-before-stirring-type fluid processing device and an immediately-before-stirring-type fluid processing method that can adjust or improve the final properties of a fluid to be processed that is introduced as a raw material into an annular flow channel of a microreactor employing the annular flow channel, which is formed between relatively rotating processing surfaces, as a flow channel in which fluid processing is performed. A fluid to be processed, which has been prepared in a fluid preparing system so as to be in an ideal state for reaction, is charged into a fluid processing device. The fluid processing device subjects the fluid to be processed to reaction processing in an annular flow channel, which is formed between two processing surfaces. A cylindrical stirring space is provided in the radially inner side of the annular flow channel, and a rotor and a screen are disposed inside the stirring space. Stirring energy is applied by the rotor and a shearing force is applied between the rotor and the screen to the fluid to be processed immediately before the fluid to be processed is introduced into the annular flow channel.

Immediately-before-stirring-type fluid processing device and processing method

The present application provides a microsphere comprising a lactic acid-glycolic acid copolymer (PLGA) or polylactide (PLA) as a main component, in which a biologically active substance is uniformly dispersed, wherein an average volume-based particle diameter of the microsphere is 1 &#x3bc;m or more and 150 &#x3bc;m or less, and a variation coefficient of area ratios in six regions is 0.35 or less, wherein the area ratios in six regions are calculated by (s/A)&#xd7;100 (%) wherein the six regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the biologically active substance in the microsphere or a higher magnification; and dividing the electron microscope observation image into six regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the biologically active substance included in the respective divided region. The microsphere of the present invention can appropriately control the initial release amount of the biologically active substance and its release rate during a subsequent release period, and can continuously release the biologically active substance in vivo for a predetermined period of time.

Microsphere comprising PLGA or PLA in which a biologically active substance is uniformly dispersed and a sustained release formulation comprising the same

A pigment composition for a green filter includes a green pigment consisting of a halogenated zinc phthalocyanine, wherein as spectral transmission characteristics of a dispersion containing only the green pigment as a pigment, the transmittance at 400 nm is 1% or less; the transmittance at 450 nm is 25% or less; the transmittance at 600 nm is 30% or less; the transmittance at 650 nm is 0.3% or less; the transmittance at the peak wavelength is 80% or more; the half value width of the peak wavelength is 120 nm or less; the transmittance at 750 nm is 1% or less; and the transmittance at 800 nm is 20% or less. The pigment composition for a green filter has low transmittance in the blue range, low transmittance in the near infrared range, and high transmittance in the green range by only a green pigment.

Pigment composition for green filter and production method thereof

The present invention addresses the problem of providing a method for efficiently producing uniform microparticles of curcumin and/or &#x3b3;-oryzanol at a higher yield. The target microparticles are produced by dissolving a starting material in a solvent to give a starting material solution and then subjecting the starting material solution to crystallization by a poor solvent method to thereby deposit the starting material. To prepare the starting material solution, curcumin and/or &#x3b3;-oryzanol are used as the starting material(s) and ethanol is used as the solvent. The starting material(s) and the solvent are stirred in a pressurized state at a temperature of 78.3-130&#xb0; C. inclusive to give the starting material solution. Then, the starting material solution thus obtained is subjected to crystallization by the poor solvent method and thus the target microparticles are produced.

Method for producing microparticles from pressurized and heated starting material solution

The problem addressed by the present invention is providing a fluid processing method including extraction that can extract material to be extracted continuously with high efficiency. In a thin film fluid formed between at least two processing surfaces () disposed facing each other so as to be able to approach to and separate from each other such that at least one rotates relative to the other, a fluid processing that extracts at least one kind of material to be extracted in at least one kind of the extraction solvent that can extract that material to be extracted is carried out. In addition, the fluid containing at least one kind of material to be extracted and a fluid for extraction that contains the at least one kind of extraction solvent are mixed in the thin film fluid formed between the at least two processing surfaces () disposed facing each other so as to be able to approach to and separate from each other such that at least one rotates relative to the other, and a fluid processing process that extracts the at least one kind of material to be extracted into the at least one kind of extraction solvent is carried out.

Fluid processing method including extraction

A method for increasing the production of fine particles is provided. The method uses at least two types of fluids to be processed, a raw material fluid containing at least one type of fine particle raw material and a fluid for treating the fine particle raw material. Fine particles are obtained by mixing the fluids to be processed in a thin film fluid formed between at least two processing surfaces which are disposed to be faced with each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other. The production of the fine particles is increased by introducing the raw material fluid from the centers of the processing surfaces.

Method for increasing production volume of fine particles using forced thin film fluid treatment apparatus

At least two types of fluids to be processed are mixed in a thin film fluid formed between at least two processing surfaces which are approachably and separably disposed facing each other. At least one processing surface rotates relative to the other, and a substance to be separated giving a controlled crystallite diameter is caused to separate. Specific conditions related to a fluid to be processed are varied to control the crystallite diameter of the substance to be separated. The specific conditions are the type of substance to be separated; the concentration of the substance to be separated included in the raw material fluid and/or substance included in the separating fluid; the pH of the raw material fluid and/or separating material fluid; the introduction temperature of the raw material fluid and/or separating fluid; and the introduction velocity of the raw material fluid and/or separating fluid.

Method for producing microparticles having controlled crystallite diameter

The problem addressed by the present invention is to provide; solid solution pigment nanoparticles having a homogeneous solid solution ratio; a method for producing solid solution pigment nanoparticles having a homogeneous solid solution ratio in each primary particle; and a method for controlling the solid solution ratio of solid solution pigment nanoparticles. The solid solution pigment nanoparticles are prepared by precipitating at least two types of pigment by mixing a pigment precipitation solvent and; at least one type of pigment solution wherein at least two types of pigment are dissolved in a solvent: or at least two types of pigment solution wherein at least one type of pigment is dissolved in a solvent. The solid solution pigment nanoparticles are wherein the solid solution ratio of the at least two types of pigment in the primary particles of the precipitated solid solution pigment nanoparticles with respect to the ratio of the at least two types of pigment in the pigment solution mixed with the pigment precipitation solvent having a precision within 25%.

Solid solution pigment nanoparticles and method for producing solid solution pigment nanoparticles having controlled solid solution ratio

The problem addressed by the present invention is to provide a method for producing microparticles. Provided is a method that is for producing microparticles and that is characterized by containing at least the following two steps: (I) a step for preparing a microparticle starting material solution by dissolving at least one type of microparticle starting material in a solvent using high speed stirring or ultrasonic waves, and (II) a step for precipitating microparticles by mixing the microparticle starting material solution and at least one type of precipitation solvent for precipitating the microparticle starting material in a thin film fluid formed between at least two processing surfaces that are disposed facing each other, are able to approach/separate from each other, and of which at least one rotates relative to the others.

Method for producing microparticles

A method for producing isolatable oxide microparticles or hydroxide microparticles using an apparatus that processes a fluid between processing surfaces of processing members that are arranged opposite each other so as to be able to approach to or separate from each other and such that at least one can rotate relative to the other. At least two fluids are mixed and oxide microparticles or hydroxide microparticles are separated, said two fluids including: a fluid containing a microparticle raw material solution comprising a microparticle raw material mixed into a solvent, and a fluid containing a microparticle-separation solution. Immediately thereafter, the following are mixed to obtain isolatable oxide microparticles or hydroxide microparticles: a fluid containing the separated oxide microparticles or hydroxide microparticles; and a fluid containing a microparticle-treatment-substance-containing solution that contains a microparticle-treatment substance that adjusts the dispersibility of the separated oxide microparticles or hydroxide microparticles.

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Izumi, Japan

Kaeko Araki