The United States Government as Represented by the Department of Veterans Affairs

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Bioventures, LLC

K Sree Kumar

Philip J Breen

Martin Hauer-Jensen

Thomas Michael Seed

Venkataraman Srinivasan

Andreas Papas

Kottayil Varughese

Thomas M Seed

Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the α-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.

Tocopherol derivatives and methods of use

The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using &#x3b3;-tocotrienol, &#x3b1;-tocopherol succinate or &#x3b3;-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of &#x3b3;-tocotrienol; or (2) oral administration of a therapeutically effective amount of &#x3b1;-tocopherol succinate or &#x3b3;-tocotrienol succinate or both.

Radiation protection by gamma-tocotrienol

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Rockville, MD, United States of America

K Sree Kumar