Brantford Chemicals Inc.

Apotex Pharmachem Inc.

K S Keshava Murthy

Daqing Che

Stephen E Horne

Allan W Rey

Bhaskar Reddy Guntoori

Yajun Zhao

Bruno K Radatus

Gamini Weeratunga

Zhi-Xian Wang

Chandrawansha B W Senanayake

Gurijala V Reddy

Fan Wang

Probal Kanti Datta

David A Stradiotto

Uma Kotipalli

Lotfi Derdour

Martin Ehlert

Shawn Young

Tania E Nish

A process for the preparation of an acid addition salt of an organic base comprising exposing the organic base in solid form to a gaseous acid, with the proviso that ziprasidone, its acid addition salts and intermediates thereof are excluded.

Preparation of acid addition salts of amine bases by solid phase&#x2014;gas phase reactions

Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications.

Atorvastatin calcium propylene glycol solvates

A process for the preparation of aminoalkyl phenyl carbamate compounds of Formula I, wherein Rand Rindependently are hydrogen or a Calkyl; Rand Rare the same or different and each is a Calkyl; or Rand Rtogether with the nitrogen to which they are attached form a cyclic three to eight membered ring, with or without a heteroatom like nitrogen or oxygen; Rand Rindependently are hydrogen, linear, branched or cyclic Calkyl; or Rand Rtogether with the nitrogen to which they are attached form a cyclic three to eight membered ring, with or without a heteroatom like nitrogen or oxygen; the carbon centre designated '*' can be racemic or enantiomerically enriched in the (R)- or (S)- configuration; and pharmaceutically acceptable acid addition salts thereof.

Process for the preparation of phenylcarbamates

A process for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester comprising:

Preparation of atorvastatin

A process for the industrial scale manufacture of 4-(4-fluorophenyl)-N-alkylnipecotinate esters by the addition of 4-fluorophenylmagnesium halide in tetrahydrofuran to 3,4-unsaturated-3-piperidine esters.

Preparation of 4-(4-fluorophenyl)-N-alkylnipecotinate esters, 4-(4-fluorophenyl)-N-arylnipecotinate esters and 4-(4-fluorophenyl)-N-aralkylnipecotinate esters

An improved catalyst is disclosed for a process involving the preparation of benzylidene intermediates useful in the preparation of 1,4-dihydropyridine compounds and derivatives thereof useful as medicines such as for example felodipine. This is accomplished by the condensation of an aldehyde and an acetoacetate in the presence of a novel catalyst system that includes a pyridyl carboxylic acid and a secondary amine. It has been found that through the use of the present invention the purity and yield of the desired isomer of the benzylidene intermediate can be maximized, thus avoiding the requirement of additional purification steps. The use of these intermediates can then be further reacted to form the required dihydropyridines, again having a very high purity and yield compared with the prior art.

Process to prepare, 1,4-dihydropyridine intermediates and derivatives thereof

There are disclosed novel Stavudine solvates as follows: Stavudine NN-dimethyllacetamide solvates; Stavudine NN-dimethylacrylamide solvates and Stavudine NN-dimethylpropionamide solvates and processes for producing Stavudine NN-dimethylacetamide solvates, Stavudine NN dimethylacrylamide solvates and Stavudine NN dimethylpropionamide solvates which results in pure Stavudine.

Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof

Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers

A process for the preparation of Nefazodone hydrochloride comprising direct conversion of semicarbazide dihydrochloride 3 into Nefazodone hydrochloride which process involves a reaction of triethyl orthopropionate in the presence of trimethylsilylchloride and hydrochloric acid.

Process for the preparation of nefazodone hydrochloride

Efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines

Useful form of anhydrous paroxetine hydrochloride

1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues

A process for manufacturing Simvastatin is provided comprising reacting lovastatin with an organic boronic acid to produce a derivative of lovastatin (lovastatin phenylboronate) methylating the 2-methylbutyryloxy group on the lovastatin derivative to form a 2,2-dimethylbutyryloxy group on the lovastatin derivative and thereafter removing the boronate group to produce simvastatin.

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Ancaster, Canada

K S Keshava Murthy