Alliance Pharmaceutical Corp.

Temple University

Biopulmonics, Inc.

K Michael Sekins

Thomas H Shaffer

Marla R Wolfson

Methods of delivering a therapeutic or diagnostic agent in a perfluorochemical liquid carrier are provided. In preferred embodiments, the disclosed methods use compositions in the form of an emulsion or a dispersion for delivery of a biological agent to the pulmonary air passages.

Methods for the pulmonary delivery of biological agents

Biocompatible fluorocarbon compositions are provided which may be used for the delivery of bioactive agents to the pulmonary air passages of a patient. Preferred compositions comprise a fluorocarbon liquid carrier having a bioactive agent in a solid or immiscible liquid form distributed therein. The disclosed compositions allow for the selective delivery of bioactive agents in conjunction with liquid lavage and liquid ventilation for the treatment of ARDS and other pulmonary disorders.

Fluorocarbon compositions for pulmonary therapy

An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.

Apparatus for pulmonary therapy

Pulmonary delivery of therapeutic agent

Apparatus for pulmonary delivery of drugs with simultaneous liquid

A hyperthermic treatment of lung cancer, by temporarily filling with a liquid medium preselected pulmonary air passages adjoining pulmonary tissues containing malignant cells, circulating exogenously heated liquid medium at from about 41.degree. to ab

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San Diego, CA, United States of America

K Michael Sekins