University of Southern California

University of California

National Yang Ming Chiao Tung University

Doheny Eye Institute

K Kirk Shung

Qifa Zhou

Mark Salman Humayun

Zhongping Chen

Eun Sok Kim

Hossein Ameri

Chien-Kun Ting

Hui-Hua Chiang

Jacques Van Dam

Jiawen Li

Thomas Matthew Cummins

Shih-Pin Lin

Xiang Li

Gerald Chader

Jay A Williams

Jonathan M Cannata

Ruibin Liu

Teng Ma

Youngki Choe

Jonathan W Kim

Xiaochen Xu

A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence subsystem for imaging. The instrumentality takes a tissue biopsy from a visible location simultaneously with the visualization of the tissue about to be biopsied so that the tissue biopsy location is visualized before, during and after the biopsy.

Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts

In some aspects of the disclosure, an apparatus includes an XYZ control stage and an acoustic transducer coupled with the XYZ control stage. The acoustic transducer includes a multi-foci Fresnel lens having multiple focal spots.

Acoustic tweezers

An ultrasonic positioning method for real time measuring the distance between the epidural needle and the epidural space is provided. The ultrasonic positioning method at least includes a puncturing step; an advancing step; a positioning step for simultaneous detecting reflected ultrasonic signals from the ligamentum flavum (LF) and dura mater (DM); a replacement step for removing the ultrasound needle transducer and putting an injecting catheter; and an injection step for injecting an anesthetic into the epidural space via the injecting catheter.

Ultrasonic positioning device for epidural space and method using the same

Systems and methods are disclosed providing for the use of ultrasound energy to measure blood flow within blood vessels by Doppler velocity measurement. Directional high-frequency pulsed-wave Doppler measurements can be made with a suitable ultrasonic needle transducers for in vivo measuring of blood flow. A needle probe can include a ultrasonic material such as PMN-PT. Such blood flow measurements can be made in any part of the body, e.g., in the central retinal vein and branch retinal veins.

Intraocular ultrasound doppler techniques

Methods and systems are described for making posts and kerfs in an interdigital bonded composite. The desired alignment criteria for a plurality of posts and kerfs in a pair of slabs are determined, as well as the desired widths W of the posts and the desired widths K of the kerfs. The posts in the first slab are configured to be received into corresponding kerfs in the second slab, and vice versa, so that the pair of slabs can be interdigitated to generate a composite. At least one of an alignment post and an alignment kerf are created, in at least one of the slabs. The alignment posts and the alignment kerf are configured to allow the plurality of posts and kerfs to be correctly positioned and aligned, in accordance with the desired alignment criteria.

Post positioning for interdigital bonded composite

Growing community of inventors

Monterey Park, CA, United States of America

K Kirk Shung