Leland Stanford Junior University

The United States of America, As Represented by the Secretary, Department of Health and Human Services

City of Hope

K Christopher Garcia

Aaron Michael Ring

Darren L Bates

Ignacio Moraga

Warren Jaye Leonard

Christine E Brown

Ignacio Moraga Gonzalez

Rosanne Spolski

Suman Mitra

Lawrence Stern

Xin Yang

Erin Elizabeth West

Aaron M Ring

Warren J Leonard

Chimeric antigen receptor molecules that include a variant IL-13. The variant IL-13 are more selective for IL13Rα2 than IL13Rα1 by virtue of weaker binding to IL13Rα1. The chimeric antigen receptors can be used to treat IL13Rα2 expressing cancers.

Targeted chimeric antigen receptor modified T cells for treatment of IL13Rα2 positive malignancies

Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for their use. These compositions encompass interleukin-4 (IL-4) muteins. The disclosed methods encompass administering an IL-4 to treat neoplastic diseases, autoimmune diseases, infectious diseases or for expanding a hematopoietic cell population.

Method of producing Th9 T-cells

Superkines and synthekines: repurposed cytokines with new and enhanced signaling activities

The invention provides a method of promoting the host defense of a patient to a bacterial infection comprising administering to a patient suffering or at risk of a bacterial infection, a pharmaceutical composition comprising an effective amount of the pleiotropic cytokine, thymic stromal lymphopoietin (TSLP) protein or polypeptide in an amount and at a location sufficient to promote the host defense of the patient to the bacterial infection. In a preferred embodiment, the bacterial infection is the infection of the patient with MRSA. The invention also provides a method of treating blood product, which comprises introducing a TSLP protein or polypeptide into such blood product, wherein the blood product is extracorporeal and comprises at least one neutrophil.

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Growing community of inventors

Menlo Park, CA, United States of America

K Christopher Garcia