Novartis Ag

Ciba Vision Corporation

Dr. H.c. Robert Mathys Stiftung

Commonwealth Scientific and Industrial Research Organisation

Novartis Pharma Gmbh

Jürgen Vogt

Dawn A Smith

Frank Chang

Arthur Ho

Yongxing Qiu

Angelika Maria Domschke

John Dallas Pruitt

Troy Vernon Holland

Daqing Wu

Xinming Qian

Richard Charles Turek

Dieter Lohmann

Lynn Cook Winterton

Bernhard Seiferling

Qin Liu

John Martin Lally

Gordon Francis Meijs

Peter Chabrecek

Judy Smith Riffle

Paul Clement Nicolson

Bronwyn Glenice Laycock

Klaus H Schindhelm

Richard Carlton Baron

Robert Mathys

Wilson Leonard Terry, Jr

Deborah Sweeney

John Court

Eric Papaspiliotopoulos

Beat Gasser

Mary Mowrey-McKee

Reto Luginbühl

Hans Jörg Griesser

Jens Höpken

Thomas Schmidt

Jorge Luis Sague Doimeadios

Yannick Loosli

Mary Flowers Mowrey-Mckee

Dawn Smith

Klaus Schindhelm

The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to methods of the invention.

Method for making silicone hydrogel contact lenses

The present invention is directed to an implant device, in particular an implant device placed between bony, cartilaginous or soft tissues or between prosthetic surfaces to restore or create a gap. More particular the present invention is directed to an implant device made from polymeric material and having a stiffness gradient as well as a limited dimensional deformation, wherein the implant device has a stiffness gradient and a limited dimensional deformation and preferably is at least partially anisotropic.

Implant device

There is described a composition for forming an contact lens, in particular for forming a silicone hydrogel contact lens, comprising at least one first vinylic monomer or macromer having one first ethylenically unsaturated group and at least one second vinylic monomer or macromer having one second ethylenically unsaturated group, wherein the first and second ethylenically unsaturated groups are different from each other and wherein the composition further comprises a crosslinker with at least two ethylenically unsaturated (polymerizable) groups with a selected kinetic copolymerization parameter rof less than 1.0 relative to one of the first and second ethylenically unsaturated (polymerizable) groups as defined above.

Composition for forming a contact lens

The present invention provides an aqueous solution for sterilizing and storing ophthalmic devices, preferably a contact lens, made of a hydrogel material, preferably a poly(oxyalkylene)-containing hydrogel material. The solution comprises one or more organic buffer agents, such as a Good buffer or a bis-aminopolyols; an organic tonicity-adjusting agent with multiple hydroxyl groups in an amount sufficient to provide an osmolarity of from about 200 to about 450 mosm/l, wherein the aqueous solution has a pH of from about 5.5 to about 8.5, provided that the aqueous solution include phosphate buffer at a concentration of about 15 mM or less and about 5000 ppm sodium chloride. The present invention also provides a method for sterilizing and storing an ophthalmic device using an aqueous solution of the invention.

Method for sterilization of hydrogel contact lenses

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Extended wear ophthalmic lens

Growing community of inventors

Flueh, Switzerland

Jürgen Vogt