Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Transgene S.a.

Deutsches Krebsforschungszentrum

Ruprecht-karls-universitat Heidelberg

Medigene Ag

Jürgen Kleinschmidt

Hugo Katus

Karsten Geletneky

Dirk Grimm

Karola Rittner

Oliver Müller

Karl Varadi

Andrea Kern

Michéle Rabreau

Jörg Schlehofer

Edda Tobiasch

Markus HÖRER

The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.

Modified AAV capsid polypeptides

The present invention relates to an AAV DNA having helper virus sequences which are necessary for developing AAV viral particles, a system containing such a DNA and the use of both.

AAV DNA comprising helper virus sequences

The present invention relates to a method of detecting a causative agent of the so-called spontaneous early abortion by investigating patients' samples for the presence of adeno-associated virias DNA (AAV DNA), or AAV antigen or antibodies, preferably of the IgM type, directed to AAV. Furthermore, the present invention relates to antibodies suitable for said method.

Adeno-associated virus-its diagnostic use with early abortion

Growing community of inventors

Bammental, Germany

Jürgen Kleinschmidt