Novartis Ag

Novartis Pharma Gmbh

Jörg Eder

Achim Schlapbach

Philipp Janser

Birgit Bollbuck

Lászlo Révész

Boerje Haraldsson

Rudolf Wälchli

Anna Svenja Schubart

René Hersperger

Richard Alexander Harrison

Alastair DenholmMritain

Rudolf Wálchi

Alastair Novartis Horsham Research Ctre Denholm

The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment of patients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Uses of piperidinyl-indole derivatives

A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables have the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent. 

2-aminopyrimidine derivatives and their medical use

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Rheinfelden, Germany

Jörg Eder